Ruth Halaban PhD
Senior Research Scientist in Dermatology
Departments & Organizations
Melanoma Program
Dermatology: Skin Diseases Research Center, Yale
Gene Regulation and Functional Genomics
Research Interests
Genes controlling differentiation, proliferation and malignant transformation of melanocytes; growth factors and receptor kinases; signal transduction; epigenetic modification and gene expression; markers for melanoma more...
Education
- Ph.D., Princeton University, 1968
Selected Publications
- Ha, B.H., M.J. Davis, C. Chen, H.J. Lou, J. Gao, R. Zhang, M. Krauthammer, R. Halaban, J. Schlessinger, B.E. Turk, and T.J. Boggon. 2012. Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A.
- Krauthammer, M., Y. Kong, B.H. Ha, P. Evans, A. Bacchiocchi, J.P. McCusker, E. Cheng, M.J. Davis, G. Goh, M. Choi, S. Ariyan, D. Narayan, K. Dutton-Regester, A. Capatana, E.C. Holman, M. Bosenberg, M. Sznol, H.M. Kluger, D.E. Brash, D.F. Stern, M.A. Materin, R.S. Lo, S. Mane, S. Ma, K.K. Kidd, N.K. Hayward, R.P. Lifton, J. Schlessinger, T.J. Boggon, and R. Halaban. 2012. Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Nat Genet. 44:1006-1014
- Halaban, R., W. Zhang, A. Bacchiocchi, E. Cheng, F. Parisi, S. Ariyan, M. Krauthammer, J.P. McCusker, Y. Kluger, and M. Sznol. 2010. PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF(WT) melanoma cells. Pigment Cell Melanoma Res. 23:190-200.
