News | DirectConnect | 2009 | 2009-10-02

October 2, 2009

October 2, 2009

Announcements

Yale Cancer Center Research Prize and Award for Clinical Excellence

We are pleased to announce two annual, competitive awards in the areas of excellence in research and clinical care for Yale Cancer Center members. All members are encouraged to apply, or nominate a colleague for one of the awards. Each award will be announced at the Yale Cancer Center Conclave on Monday, November 23, 2009.
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Yale Cancer Center Grand Rounds

We continue to have excellent attendance at our weekly Grand Rounds. Thank you for making time in your schedule to attend. I look forward to seeing Yale Cancer Center members each Tuesday at noon in Brady Auditorium for the presentations.
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United Way

Yale University has launched our annual United Way campaign. Please consider making a gift to support the Greater New Haven community. This is one way that Yale Cancer Center can give back to the community that supports us.
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Notables

Daniel DiMaio, MD, PhD, George Miller, MD, and Joan Steitz, PhD

were awarded a renewal of their program project grant from the

National Cancer Institute

in Tumor Virology. The grant, Molecular Basis of Viral and Cellular Transformation, is for $8 million over the next 5 years.

Judith Grasso, RN

has been promoted to the role of

Patient Services Manager

for the Oncology Service Line. In this new role, Judy oversees the Medical Oncology solid and liquid tumor services at the Long Wharf and Yale Physician's Building facilities. Her role will expand with the opening of the Smilow Cancer Hospital at Yale-New Haven.

The V Foundation for Cancer Research

recently awarded

Qin Yan, PhD

a $200,000 grant to study the role of histone demethylase retinoblastoma binding protein 2 in cancer. Dr. Yan's research will determine the impact of histone demethylase RBP2 on oncogenesis and how its activity contributes to the malignant transformation of cells.

Smilow Update

As the week of October 26th fast approaches, construction is focused on the Lower Level where Radiation Oncology will see and treat patients, as well as the first floor lobby. Radiation Oncology will be the first unit to care for patients at the new Smilow Cancer Hospital at Yale-New Haven. Punchlist items are being addressed by the various subcontractors, furniture is starting to be delivered, and coral is being placed into the Lower Level aquarium.

New Clinical Trial Available

HIC Number 0904005078

Principal Investigator: Jonathan Knisely, MD
A Phase III Double-Blind, Placebo-Controlled Trial of Conventional Concurrent Chemoradiation and Adjuvant Temozolomide Plus Bevacizumab Versus Conventional Concurrent Chemoradiation and Adjuvant Temozolomide in Patients with Newly Diagnosed Glioblastoma
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Shared Resource Highlight

Proteomics Shared Resource (PSR)

The Yale Cancer Center Proteomics Shared Resource (PSR) brings state-of-the-art technologies to cancer research. These technologies include a wide range of mass spectrometry, protein identification, and protein profiling technologies, along with biophysical technologies. The latter technologies can be used to quantitatively study protein:protein and protein:ligand interactions which complement and greatly extend the range of available proteomic analyses.

Applications:

Provide exact/accurate molecular weight information on peptides, proteins, small molecules, oligonucleotides, and other biomolecules that may extend past 100,000 daltons through both mass spectrometry and in solution methods
Quantitatively profile relative protein expression in multiple complex proteomes
Identify and locate protein post-translational modifications
Detect and characterize synthetic intermediates (<5 ppm error on <1,000 dalton compounds)
Identify proteins via MS/MS analysis of in gel tryptic digests
Quantitatively (affinity and kinetics) analyze protein:protein and protein:ligand interactions

Kathy Stone, MD, co-Director
(203) 737-2206

Ewa Folta-Stogniew, co-Director
(203) 737-4387

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Recent Publications

Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor.

Talbert-Slagle K, Marlatt S, Barrera FN, Khurana E, Oates J, Gerstein M, Engelman DM, Dixon AM, Dimaio D.
J Virol. 2009 Oct;83(19):9773-85. Epub 2009 Jul 15.
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Harnessing CD1d-restricted T cells toward antitumor immunity in humans.

Neparidze N, Dhodapkar MV.
Ann N Y Acad Sci. 2009 Sep;1174:617.
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Glutathione S-transferase polymorphisms and survival in African-American and White colorectal cancer patients.

Jones BA, Christensen AR, Wise JP Sr, Yu H.
Cancer Epidemiol. 2009 Sep 11.
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Structural similarity assessment for drug sensitivity prediction in cancer.

Shivakumar P, Krauthammer M.
BMC Bioinformatics. 2009 Sep 17;10 Suppl 9:S17.
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Capecitabine treatment patterns in patients with gastroesophageal cancer in the United States.

Saif MW, Shi N, Zelt S.
World J Gastroenterol. 2009 Sep 21;15(35):4415-22.
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