Yale Cancer Center Annual Retreat
Please save the date for our annual research retreat, scheduled to be held on
Monday, May 10th at Yale's West Campus . I am looking forward to a collaborative day and will be contacting research program and shared resource leadership in the coming weeks to begin planning the program.
Publication Submissions and Presentations
The Cancer Center includes a remarkable group of clinicians, scientists, and investigators. It is essential that we get the word out to the public and our colleagues that we are all members of an NCI designated comprehensive cancer center. I would like to remind Yale Cancer Center members to include their Cancer Center and Smilow Cancer Hospital at Yale-New Haven affiliation when submitting manuscripts for publication.
In addition, I urge you to use the Yale Cancer Center and Smilow Cancer Hospital slide decks whenever possible at local, national, and international meetings. The templates can be downloaded through the Yale Cancer Center website and used for both academic or patient lectures.
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Smilow Update
The final stages of building completion are on schedule at Smilow Cancer Hospital. At this time there are about 150 workers on site each day. Construction is finished on the inpatient Intensive Care Units of the Hospital, floors 9 and 10, and the hospital building staff is in the process of finalizing the space. In addition, furniture and fixtures are being installed on floors 4, 7, and 8.
The physicians of the Hematology Program will begin seeing their patients on the 7th floor of the building on February 22nd. The Pediatric Hematology and Oncology Program will move the following week.
Beginning on February 22nd, the 4th floor of the Air Rights Garage will be available for patients at Smilow Cancer Hospital for a flat fee of $4. The valet parking rate will increase to $10 per visit at that time.
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Dr. Stephan Ariyan , Director of the Yale Cancer Center Melanoma Program, Clinical Professor of Surgery, and Associate Chief of Surgery at Yale-New Haven Hospital, is a
2010 Distinguished Fellow of the American Association of Plastic Surgeons . This award recognizes his personal achievements and lifetime contributions to the field of plastic surgery and will be given to him in March at the Association's annual meeting in San Antonio.
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Disarming Specialized Stem Cells Might Combat Deadly Ovarian Cancer
Eliminating cancer stem cells within a tumor could hold the key to successful treatments for ovarian cancer, which has been notoriously difficult to detect and treat, according to new findings published this week in the journal
Oncogene by Yale School of Medicine researchers.
Dr. Yingun Huang, Assistant Professor in the Department of Obstetrics, Gynecology & Reproductive Sciences, and her colleagues found that stopping the expression of two genes - Lin28 and Oct4 - reduces ovarian cancer cell growth and survival.
Women with Variants in "CLOCK" Gene Have Higher Risk of Breast Cancer
A Yale University-led team of researchers has demonstrated for the first time that variants in a gene responsible for regulating the body's circadian rhythm may lead to breast cancer. The study appears as an OnlineFirst publication of the journal Cancer Research.
Led by Yong Zhu, PhD, co-director of the Yale Cancer Center Prevention and Control Program, the research team showed that genetic and epigenetic changes in the "CLOCK" gene, which is a key component of the molecular circadian regulatory system and enhances the expression of a variety of genes, may trigger breast cancer susceptibility.
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American Cancer Society Institutional Research Grant
Yale Cancer Center is pleased to announce a call for applications for the American Cancer Society's Institutional Research Grant (ACS IRG). The awards are to support innovative work in the broad field of basic, translational, clinical and prevention/control cancer research by new investigators.
Assistant Professors during the term of the award are eligible to apply. Investigators may not apply who have previously received an ACS IRG award or a competitive national research grant, unless it is primarily for salary support. One-year grants up to $30,000 each will be awarded and will commence on April 1, 2010.
For further information, please contact Jan Zulkeski. The deadline for submission is 4:00 PM on Wednesday, February 24, 2010.
Learn More >>
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Newly Opened Clinical Trials
Principal Investigator: Scott Gettinger, MD
A Study of Ridaforolimus (AP23573/MK-8669) in Non-Small Cell Lung Cancer Patients with KRAS Mutations
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Recent Publications
Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion.
Wu M, Pastor-Pareja JC, Xu T.
Nature. 2010 Jan 28;463(7280):545-8.
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Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer.
Peng S, Maihle NJ, Huang Y.
Oncogene. 2010 Jan 25.
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Cetuximab and First-Line Taxane/Carboplatin Chemotherapy in Advanced Non-Small-Cell Lung Cancer: Results of the Randomized Multicenter Phase III Trial BMS099.
Lynch TJ, Patel T, Dreisbach L, McCleod M, Heim WJ, Hermann RC, Paschold E, Iannotti NO, Dakhil S, Gorton S, Pautret V, Weber MR, Woytowitz D.
J Clin Oncol. 2010 Jan 25.
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Exploiting cellular senescence to treat cancer and circumvent drug resistance.
Yan Q, Wajapeyee N.
Cancer Biol Ther. 2010 Feb 11;9(3).
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ATA practice guidelines for the treatment of differentiated thyroid cancer: were they followed in the United States?
Famakinwa OM, Roman SA, Wang TS, Sosa JA.
Am J Surg. 2010 Feb;199(2):189-98.
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Management of patients with advanced non-small cell lung cancer: current and emerging options.
Triano LR, Deshpande H, Gettinger SN.
Drugs. 2010;70(2):167-79.
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Surveillance epidemiology and end results evaluation of the role of surgery for stage I small cell lung cancer.
Yu JB, Decker RH, Detterbeck FC, Wilson LD.
J Thorac Oncol. 2010 Feb;5(2):215-9.
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Metachronous primary melanoma and lymphoma.
McIntosh BC, Ariyan S, Esche G, Zelterman D, Narayan D.
Ann Plast Surg. 2010 Feb;64(2):229-32.
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EBNA1 regulates cellular gene expression by binding cellular promoters.
Canaan A, Haviv I, Urban AE, Schulz VP, Hartman S, Zhang Z, Palejev D, Deisseroth AB, Lacy J, Snyder M, Gerstein M, Weissman SM.
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22421-6.
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Colorectal cancer in review: the role of the EGFR pathway.
Saif MW.
Expert Opin Investig Drugs. 2010 Jan 24.
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Phase I study of the botanical formulation PHY906 with capecitabine in advanced pancreatic and other gastrointestinal malignancies.
Saif MW, Lansigan F, Ruta S, Lamb L, Mezes M, Elligers K, Grant N, Jiang ZL, Liu SH, Cheng YC.
Phytomedicine. 2010 Jan 19.
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Population Based Cancer Registry Analysis of Primary Tracheal Carcinoma.
Urdaneta AI, Yu JB, Wilson LD.
Am J Clin Oncol. 2010 Jan 15.
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Image of the month--quiz case. Metastatic renal cell carcinoma to the pancreas.
Mishra B, Grandhige G, Salem RR.
Arch Surg. 2010 Jan;145(1):101-2.
Read More >>
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| Inside Yale Cancer Center
2010 Lung Cancer Symposium
Share the invitation to the event on March 27th with your patients.
Yale Cancer Center Grand Rounds
Video presentations from Yale Cancer Center members are now available online.
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DirectConnect Archives
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Events
February 7; 6:00 PM
Yale Cancer Center Answers
WNPR 90.5
Cancer Prevention
Yawei Zhang, PhD
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February 9; 12:00 PM
Yale Cancer Center Grand Rounds
Brady Auditorium
Breast Cancer Genomics: Therapeutic Applications
Lyndsay N. Harris, MD
The Role of Ovarian Cancer Stem Cells in Recurrence and Metastases
Gil G. Mor, MD, PhD
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February 10; 6:00 PM
Understanding Cancer Lecture Series
YNHH East Pavilion Cafeteria
Living with Lymphoma
Dennis Cooper, MD
February 14; 6:00 PM
Yale Cancer Center Answers
WNPR 90.5
Pancreatic Cancer
Wasif Saif, MD
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February 16; 12:00 PM
Yale Cancer Center Grand Rounds
Brady Auditorium
Hypoxia, DNA Repair, and Cancer Therapy
Peter M. Glazer, MD, PhD
Stereotactic Body Radiotherapy for Liver Tumors
Bryan W. Chang, MD
Learn More >>
February 16; 5:00 PM
Signal Transduction Research Program Conference
Genetics Conference Room, S-116
Adhesion Molecules in Glioblastoma Migration: Novel Roles of SynCAM Immunoglobulin Proteins
Thomas Biederer, PhD
February 19; 8:00 AM
NCI Cancer Biobank (caHUB) Public Meeting
Bethesda, MD
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Submissions
Please submit your recent publication and grant announcements to:
Renee Gaudette
Director, Public Affairs and Marketing
renee.gaudette@yale.edu
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