| Ruslan M. Medzhitov, PhD Elected to the National Academy of Sciences
Earlier this week, Ruslan was announced as the newest member of the National Academy of Sciences from Yale University. Ruslan's research on innate immunity has made groundbreaking progress in the exploration of the relationship between innate and adaptive immunity. He joins 11 other members of Yale Cancer Center who are distinguished members of the National Academy of Sciences.
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Erin Hofstatter, MD Joins Yale Cancer Center
I am pleased to announce that Erin will join Yale Cancer Center and Smilow Cancer Hospital on August 1st as Assistant Professor of Medical Oncology. Erin joins us from Beth Israel Deaconess Medical Center and will care for patients in the breast cancer program. Her research and clinical focus is on high-risk genetic causes of cancer.
Membership Retreat on May 10th
Please join us for Yale Cancer Center's annual membership retreat on Monday, May 10th at the West Campus. The Annual Retreat is the single most important Cancer Center event each year, serving as a venue for members to forge collaborative relationships. Thus for several reasons, your attendance is key to a successful Retreat and Cancer Center; as an opportunity to establish and strengthen relationships with new and long-standing Center members; to learn of new and on-going research conducted by Center members; and to learn about the Cancer Center and West Campus Core Resources directly from the resource directors. Please RSVP to Paula O'Mara.
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Yale Cancer Center Researchers Identify Targets of Natural Immunity to Cancer Stem Cells in Humans
Yale Cancer Center scientists, Dr. Madhav Dhodapkar and Dr. Kavita Dhodapkar, have discovered that OCT4, a protein critical in determining the fate of certain germ-cell tumors, is commonly detected and targeted by the immune system in healthy individuals. Their findings, published in the
Proceedings of the National Academy of Sciences on April 19, could lead to the development of new vaccines and therapies to target stem cells in several cancers, by boosting this naturally occurring response.
Carbon Nanotubes Boost Cancer-Fighting Cells
Yale University engineers have found that the defects in carbon nanotubes cause T cell antigens to cluster in the blood and stimulate the body's natural immune response. Their findings, which appear as the cover article of the April 20 issue of the journal
Langmuir , could improve current adoptive immunotherapy, a treatment used to boost the body's ability to fight cancer. The study was led by Tarek Fahmy, PhD, a member of the Developmental Therapeutics Research Program at Yale Cancer Center.
Chromosome's Guardians Susceptible to UV Radiation
The molecular caps at the ends of chromosomes that protect humans against cancer and premature cellular aging show a surprising inability to protect themselves against ultraviolet radiation, a new Yale School of Medicine study led by Douglas Brash, PhD, has found. Brash is a member of the Yale Cancer Center Radiobiology and Radiotherapy Research Program.
Telomeres-the repeat sequences of DNA at the end of chromosomes that act like plastic tips at the end of a shoelace-are much more likely to be damaged by UV radiation than are other common cellular structures, researchers report in the study published online April 29 in the journal
PLoS Genetics
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Join us at the Connecticut Challenge
"Yale, Smilow and Friends" for the 6th annual
Connecticut Challenge - a fantastic and fun bike ride to support cancer survivors this summer. All ages and abilities are welcome to ride. Now in its 6th year, the Connecticut Challenge is an annual ride with participants choosing distances of 12, 25, 50, 75 and 100 miles.
The Connecticut Challenge began in partnership with Yale Cancer Center to establish the adult survivorship clinic that bears its name, provide funding to the HEROS clinic for survivors of childhood cancers, and fund pilot grants in survivorship at YCC. In 2009, it expanded its network of sites that offer survivor programming and services across the state, maintaining Yale Cancer Center as its flagship site and founding partner.
This year's ride begins and ends in Fairfield on Saturday, July 24, 2010. Many throughout the Yale community have ridden in past years and we invite you to join us again or for the first time! Bikes are available for rent at the ride. Please read all the ride and fundraising information carefully and if you choose to ride, please join the team "Yale, Smilow and Friends." If you wish to simply support the team with a donation please do so!
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Team Tri-Captains
Melinda Irwin
Robert Dubrow
Peter Lamothe
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Yale Center for Analytical Sciences (YCAS)
The Yale Center for Analytical Sciences (YCAS) was recently established to bring together existing academic strengths in biostatistics, epidemiology, health economics, and health services research at the Yale School of Public Health and collaborative staff to provide expertise for the design, conduct and analysis of health and health care studies, methodological development and education and training to Yale and the extended research community. Yale Cancer Center members have access to the support of YCAS through a collaborative agreement to create a biostatistical shared resource. In addition, YCAS provides support to the YCC Protocol Review and Quality Assurance, Compliance Safety committees (QUACS).
The Key Functions of the Biostatistics Shared Resource are to: - Assist YCC investigators in the design, conduct and analysis of clinical trials, genomic and proteomic studies as well as population, epidemiologic and prevention studies of cancer.
- Provide review and evaluation of statistical design of studies for the Protocol Review Committee and monitoring of studies for QUACS.
- Provide statistical collaboration for YCC investigators on grant/protocol preparation - statistical design, power and sample size considerations, and analytic and monitoring plans.
- Assist YCC investigators with manuscript preparation and review.
- Organize workshops and training to educate YCC investigators on the statistical aspects of study design and analysis of cancer studies.
YCAS research design clinics are held every Wednesday from 12 to 2 PM in Room 108 in the School of Public Health. Clinics are free of charge. To schedule an appointment, please contact YCAS and provide a short description of your research question.
Program Directors:
Peter Peduzzi, PhD(203) 785-5651
James Dziura, PhD(203) 737-4468
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Recent Publications
Trastuzumab sensitizes ovarian cancer cells to EGFR-targeted therapeutics.
Wilken JA, Webster KT, Maihle NJ.
J Ovarian Res. 2010 Mar 27;3(1):7.
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Molecular Imaging of N-linked Glycosylation Suggests Glycan Biosynthesis is a Novel Target for Cancer Therapy.
Contessa JN, Bhojani M, Freeze HH, Ross BD, Rehemtulla A, Lawrence TS.
Clin Cancer Res. 2010 Apr 22.
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Alemtuzumab as a bridge to allogeneic SCT in atypical hemophagocytic lymphohistiocytosis.
Strout MP, Seropian S, Berliner N; Medscape.
Nat Rev Clin Oncol. 2010 Apr 20.
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Natural immunity to pluripotency antigen OCT4 in humans.
Dhodapkar KM, Feldman D, Matthews P, Radfar S, Pickering R, Turkula S, Zebroski H, Dhodapkar MV.
Proc Natl Acad Sci U S A. 2010 Apr 19.
Read More >>
TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214.
Yin G, Chen R, Alvero AB, Fu HH, Holmberg J, Glackin C, Rutherford T, Mor G.
Oncogene. 2010 Apr 19.
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Coping with the unexpected at surgery.
Detterbeck FC, Terrien CM.
Expert Rev Respir Med. 2010 Feb;4(1):115-22.
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A breakthrough in Hodgkin's disease.
DeVita VT Jr.
Nat Rev Clin Oncol. 2010 Apr;7(4):179.
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Polypharmacy in Older Adults with Cancer.
Maggiore RJ, Gross CP, Hurria A.
Oncologist. 2010 Apr 24.
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Inside Yale Cancer Center
Subscribe to Yale Cancer Center Answers on iTunes
Yale Cancer Center's weekly radio program on CT Public Radio is ranked number 2 in the world for cancer programs on iTunes. Subscribe to the show.
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Cancer Bytes
Hosted by Ellen Matloff, listen to the interviews online.
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Yale Cancer Center Grand Rounds
Video presentations from Yale Cancer Center members are now available online.
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DirectConnect Archives
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Events
April 30; 1:00 PM
Cancer Genetics and Genomics Research Program Conference
SHM C-428
OncomIR Addiction in Mouse Model of Cancer
Pedro Medina, PhD
April 30; 1:00 PM
Molecular Virology Research Program Conference
SHM I-116
The Dynamic Role of the Parvoviral Capsid in Packaging, Targeting, and Uncoating
Peter Tattersall, PhD
May 2; 6:00 PM
Yale Cancer Center Answers
WNPR 90.5
Skin Cancer Awareness
David Leffell, MD
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May 4; 12:00 PM
Yale Cancer Center Grand Rounds
55 Park Street
Attacking the Raf Pathway with Novel Kinase Inhibitors
Gideon Bollag, PhD
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May 4; 5:00 PM
Breast Cancer Clinical Seminar Series
WWW 208
Indications for Radiation Therapy after Neoadjuvant Chemotherapy
Daniel Chamberlain, MD
May 6; 6:30 PM
Breast Reconstruction Options
YNH Shoreline Medical Center
Michael Matthews, MD
May 10; 8:30 AM
Yale Cancer Center Annual Scientific Retreat
West Campus
May 12; 12:00 PM
Pediatrics Grand Rounds
Fitkin Ampitheatre
Personalized Medicine and its Implications for Children with Cancer
Thomas Lynch, Jr., MD
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Submissions
Please submit your recent publication and grant announcements to:
Renee Gaudette
Director, Public Affairs and Marketing
renee.gaudette@yale.edu
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