Michael Kashgarian MD
Professor Emeritus of and Senior Research Scientist in Pathology
Transport ATPases, Ischemic Cell Injury, Heat Shock proteins, Mechanisms of Glomerular Sclerosis. Clinical Interests: renal pathology, diagnostic electron microscopy, genetic pathology. Other interests include advanced imaging techniques, confocal microscopy, image analysis, vital microscopy.
Extensive Research Description
Research in this laboratory is directed in three main investigative areas. We study the structural and functional characteristics of transporting epithelia, in particular the cellular mechanisms involved in adaptive changes in response to steroid hormones and changes in the external ionic milieu. The second area of investigation is of the mechanisms involved in the recovery from acute renal failure. These studies concentrate on the contribution of the cytoskeleton to the reorganization of the micro domain distribution of Na,K-ATPase as well as investigating the role of the synthesis and recycling of integral membrane proteins and the contribution of heat shock proteins in this process. Finally, we are also investigating the factors involved in the initiation and progression of glomerulus scarring by defining the pathogenetically relevant parameters of progressive glomerular injury.
Renal Disease, renal transport and ischemia, heat shock proteins, diabetic nephropathy, Electron Microscopy; juvenile diabetes. Cellular disruption and restitution. Diabetes endocrinology.