Rossitza Lazova MD

Associate Professor of Dermatology and of Pathology; Director, Yale Dermatopathology Fellowship

Research Interests

Spitz nevi; Spitzoid melanocytic neoplasms; Malignant melanoma; Melanocytic nevi on special anatomic sites; Atypical Spitzoid neoplasms

Research Summary

My main interest is in Spitz’s nevi, Spitzoid malignant melanomas, and Atypical Spitzoid melanocytic neoplasms. Other interests of mine are melanocytic nevi on special anatomic sites and their histologic characteristics and malignant melanoma. I am also interested in melanomas with heavily pigmented and multinucleated melanocytes, presumably hybrids with melanophages.

Extensive Research Description

My main interest is in melanocytic lesions, particularly malignant melanoma, Spitzoid malignant melanoma, Spitz’s nevi, and Atypical Spitzoid neoplasms. I am also interested in melanomas with heavily pigmented and multinucleated melanocytes, presumably hybrids with melanophages.

Selected Publications

  • 21. Lazova R, Seeley EH, Keenan M, Gueorguieva R, Caprioli RM. Imaging mass spectrometry – a new and promising method to differentiate Spitz nevi from Spitzoid malignant melanomas. American Journal of Dermatopathology 2012, 34(1): 82-90.
  • 23. Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi R, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clinical Cancer Research 2012, 18(2): 370-379.
  • 25. Zayour M, Bolognia JL, Lazova R. Multiple Spitz nevi: A clinicopathologic study of 9 patients. Journal of the American Academy of Dermatology 2012, 67:451-458.
  • 27. Mason A, Wititsuwannakul J, Klump V, Lott J, Lazova R. p16 expression does not differentiate between Spitz nevi and Spitzoid malignant melanomas. Journal of Cutaneous Pathology 2012, 39(12): 1062-74.
  • 28. Wititsuwannakul J, Mason A, Klump V, Lazova R. Neuropilin-2 (NRP2) as a useful marker in the differentiation between Spitzoid malignant melanoma and Spitz nevus. Journal of the American Academy of Dermatology, 2013; 68(1): 129-37.
  • 31. Broer PN, Walker ME, Goldberg C, Buonocore S, Braddock DT, Lazova R, Narayan D, Ariyan S. Desmoplastic Melanoma: A 12-Year Experience with Sentinel Lymph Node Biopsy. European Journal of Surgical Oncology 2013, 39(7): 681-5.
  • 32. Lazova R, Laberge GS, Duvall E, Spoelstra N, Klump V, Sznol M, Cooper D, Spritz RA, Chang JT, Pawelek JM. A melanoma brain metastasis with a donor-patient hybrid genome following bone marrow transplantation: First evidence in human cancer. PLoS One, 2013; 8(6): e66731.
  • 33. Scortegagna M, Ruller C, Feng Y, Lazova R, Kluger H, Li JL, De SK, Rickert R, Pellecchia M, Bosenberg M, Ronai ZA. Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of BrafV600E::Pten–/– melanoma. Oncogene, 2014; 33(34):4330-9.
  • 35. Semkova K, Lott JP, Lazova R. Clinicopathologic features and survival in Spitzoid malignant melanoma and conventional malignant melanoma. Journal of the American Academy of Dermatology, 2014; May 15. pii: S0190-9622 (14) 01362-0. doi: 10.1016/j.jaad.2014.04.012. [Epub ahead of print]

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