Barbara Ann Burtness, MD

Professor of Medicine (Medical Oncology); Clinical Research Program Leader, Head and Neck Cancers Program ; Co-Director, Developmental Therapeutics Research Program

Research Interests

Drug Therapy; Head and Neck Neoplasms; Medical Oncology; Chemicals and Drugs; Analytical, Diagnostic and Therapeutic Techniques and Equipment

Research Organizations

Medical Oncology: Subset Medical Oncology Faculty

Cancer Center: Developmental Therapeutics

SWIM

Research Summary

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, including studies of treatment deintensification in HPV-associated cancer, and molecularly guided post-operative therapy. She chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer.

Specialized Terms: EGFR expressed head and neck cancers.

Extensive Research Description

Studies of targeted treatments for EGFR expressed head and neck cancers, including biomarkers of resistance and novel strategies such as dual EGFR blockade, to overcome resistance. She has demonstrated that loss of PTEN indicates resistance to EGFR inhibition in head and neck cancer, and studied novel dual EGFR/HDAC inhibitors and combined antibody and tyrosine kinase inhibition as strategies to improve responsiveness to EGFR inhibition. She leads the ECOG-ACRIN Head and Neck Therapeutics Committee, which conducts large multicenter trials in head and neck cancer, and chairs multicenter trials of targeted therapy and immunotherapy in head and neck cancer. Her laboratory studies novel combinatorial therapies to target p53 mutated head and neck cancer.

Selected Publications

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Contact Info

Barbara Ann Burtness, MD
Patient Care Location
Yale Cancer CenterSmilow Cancer Hospital at Yale - New Haven
35 Park Street, Ste NP - 4

New Haven, CT 06511
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Mailing Address
25 York Street
PO Box 208028

New Haven, CT 06520-8028