Bernard G Forget, MD

Professor Emeritus of Medicine (Hematology)

Research Interests

Genetics; Hematology; Hematopoietic Stem Cells; Stem Cells; Erythroid Cells

Research Organizations

Cancer Center, Yale

Stem Cell Center, Yale: Stem Cell Niche and Homing | Transcriptional Regulation of Stem and Progenitor Cells

Research Summary

Dr. Forget's laboratory is involved in a research program studying the regulation of gene expression in hematopoietic cells, with an emphasis on erythroid-specific gene expression. Work is devoted to: study of the transcriptional regulation of genes encoding red cell membrane skeleton proteins such as spectrin and ankyrin; study of the molecular basis of mutations of these genes that cause hereditary anemias; and study of differential gene expression in highly enriched primitive hematopoietic stem cells. The study of the regulation of tissue-specific gene expression and hematopoietic stem cell-specific gene expression is relevant to the elucidation of mechanisms responsible for abnormal gene expression in genetic and acquired disorders of blood cells, and to research directed at the purification and manipulation of reconstituting hematopoietic stem cells for the purposes of gene therapy.

Specialized Terms: Molecular Genetics of Erythroid Cell Differentiation; Hematopoietic Stem Cell Biology

Extensive Research Description

Hematopoiesis provides an excellent model system for the study of gene expression and the molecular basis of disease. In hematopoietic cells, a number of genes are expressed in a tissue-specific and developmentally regulated fashion. Furthermore, a number of inherited and acquired disorders of hematopoietic cells are due to mutations that result in abnormal expression of these specialized genes.

Selected Publications

  • The normal structure and regulation of human globin gene clusters. Forget, B.G. and Hardison, R.C., In: Disorders of Hemoglobin. 2nd Ed. Steinberg, M.H., Forget, B.G., Higgs, D.R., Weatherall, D.J. (eds). Cambridge Univ. Press, New York, pp. 46-61, 20
  • Thalassemia Syndromes Giardina PJ, Forget BG. In: Hoffman R et al, eds. Hematology: Basic Principles and Practice. 5th ed. Philadelphia, PA: Churchill Livingstone; 2008:535–563.
  • Tolpinrud, W., Maksimova, Y.D., Forget, B.G., Gallagher, P.G. Nonsense mutations of the alpha spectrin gene in hereditary pyropoikilocytosis. Haematologica. 93:1752-1754, 2008.
  • Sangerman, J., Maksimova, Y., Edelman, E.J., Morrow, J.S., Forget, B.G., Gallagher, P.G. Ankyrin-linked hereditary spherocytosis in an African-American kindred. Am. J. Hematol. 83:789-794, 2008.
  • Kieusseian, A, Chagraoui, J., Kerdudo C, Mangeot, P., Gage, P., Navarro, N., Izac, B., Uzan, G., Forget, B.G., Dubart-Kupperschmitt, A. Expression of Pitx2 in stromal cells is required for normal hematopoiesis. Blood 107:492-500, 2006.
  • Zhang, H., Degar, B., Rogoulina, S., Resor, C., Booth, C., Sinning, J., Gage, P., Forget, B.G. Hematopoiesis following disruption of the Pitx2 homeodomain gene. Exp. Hemat. 34: 167-178, 2006
  • Forget, B.G. De novo and acquired forms of alpha thalassemia. Curr. Hematol. Rep. 5;11-14, 2006.

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Contact Info

Bernard G Forget, MD
Patient Care Location
Yale HematologySmilow Cancer Hospital at Yale - New Haven
35 Park Street, Fl 11th

New Haven, CT 06511
Lab Location
300 George Street, Ste 787
New Haven, CT 06511
Office Location
300 George Street, Ste 786
New Haven, CT 06511
Mailing Address
PO Box 208021
333 Cedar Street

New Haven, CT 06520-8021