Demetrios Braddock, MD, PhD

Associate Professor of Pathology; Medical Director, Precipio Diagnostics

Research Interests

Calcification, Physiologic; Osteoarthropathy, Primary Hypertrophic; Pathology; Pseudoxanthoma Elasticum; Sickle Cell Trait; Rare Diseases; Vascular Calcification

Research Organizations

Pathology: Braddock Lab | Pathology Research

Cancer Center: Genomics, Genetics, and Epigenetics

Discovery to Cure Internship

Faculty Research

Gene Regulation and Functional Genomics

Structural Biology

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Summary

  • Structural biology of protein complexes implicated in the pathogenesis of cancer
  • Genetic transcription

Specialized Terms; Structural biology; Hematopathology; Genitourinary Pathology

Extensive Research Description

My group is primarily interested in biochemical and structural aspects of blood disorders. We have recently described two endothelial enzymes within the brain vasculature that promote platelet aggregation and calcification. Polymorphisms in one of these enzymes has recently been discovered to confer stroke protection to pediatric sickle cell patients, and calcification disorders that include neonatal orphan diseases. We have recently developed a recombinant biologic to correct metabolic imbalances induced in these disorders, and validated the efficacy of the biologic in rodent models of disease.

Selected Publications

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Contact Info

Demetrios Braddock, MD, PhD
Patient Care Location
Yale PathologyYale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Office Location
Department of PathologyLauder Hall
310 Cedar Street, Rm LH 404A

New Haven, CT 06510
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Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Curriculum Vitae