In Vitro Treatment of Chemotherapy Resistant Human Ovarian Cancer by Administration of CPE

Trial Purpose and Description

Using Clostridium perfringens enterotoxin (CPE), to target ovarian cancer cells based on their high levels of claudin-3 and -4 potentially represents a novel, highly effective therapeutic approach to treat metastatic and/or chemotherapy-resistant ovarian cancer.

Participation Guidelines

Gender: Both

Yale Cancer Center

Dates: 05/29/2008 - 04/04/2012

Last Updated: 09/24/2015

Study HIC#: 0804003671

Clinical Trial

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Martha Luther

Principal Investigators

Peter E Schwartz


Stefania Bellone


Masoud Azodi


Dan-Arin Silasi


Alessandro D. Santin

Principal Investigator