Preston C. Sprenkle, MD

Assistant Professor of Urology

Departments & Organizations

Cancer Center, Yale: Developmental Therapeutics | Prostate and Urologic Cancers Program

Office of Student Research

Urology: General Urology | Robotic Surgery and Laparoscopy | Urologic Oncology

Yale Medical Group


Preston Sprenkle, M.D., earned his medical degree from Columbia University College of Physicians and Surgeons and completed his residency in urology at New York Presbyterian Hospital, Columbia Campus. Fellowship trained in urologic oncology at Memorial Sloan-Kettering Cancer Center, Dr. Sprenkle specializes in urologic cancers including prostate cancer, kidney cancer, bladder cancer, testicular cancer, and sarcoma.

He is dedicated to improving the treatment and diagnosis process for patients with urologic cancers and to creating a personalized approach for each of his patients. He views the journey toward health as a partnership with his patients and invites them to play an active role in decisions regarding their treatment process. His combined knowledge of urologic cancers and his surgical expertise in traditional, minimally invasive, and advanced surgical techniques, such as robotic-assisted minimally invasive surgery, allows him to provide his patients with the best treatment options for their specific condition and unique needs while considering their preferences, goals, and concerns. His advanced surgical techniques include nerve-sparing prostatectomy, partial nephrectomy, cystectomy, and lymph node dissection.

His research interests include prostate cancer active surveillance for cases that do not require surgery or radiation, working with new imaging technology to improve the diagnosis of prostate cancer, finding a way to use current imaging technology to improve prostate cancer biopsy procedures with the future hope of eliminating the need for unnecessary biopsies, and creating focal therapy for prostate cancer. Dr. Sprenkle has implemented the use of the Artemis Device, an MRI-ultrasound 3-D imaging and navigation technology for targeted biopsy of prostate lesions. In addition to targeted biopsy, he is initiating a focal therapy protocol for treating prostate cancer lesions rather than the whole prostate, and consequently minimizing the many side effects associated with prostate cancer treatment.

Education & Training

MD Columbia University (2004)
BA Stanford University, Human Biology (1998)
Fellowship Memorial Sloan Kettering Cancer Center
Residency New York Presbyterian Hospital
Internship New York Presbyterian Hospital
Board Certification AB of Urology (2014)

Honors & Recognition

  • Best Poster Podium PresentationYoung Urologic Oncologist dinner, Society Of Urologic Oncology Annual Meeting (2009)

  • Finalist - NY section AUA Valentine Essay ContestNY Academy of Medicine (2009)

  • Finalist - NY section AUA Valentine Essay ContestNY Academy of Medicine (2007)

  • First Prize - NY section AUA Valentine Essay ContestNY Academy of Medicine (2006)

  • Arnold P. Gold Humanism in Medicine Honors Society (2004)

  • Alpha Omega Alpha Medical School Honors Society (2004)

  • Outstanding Member of Stanford CommunityStanford University (1998)

  • Member, Board of DirectorsStanford University Alumni Association (1997)

Professional Service

  • NCCN Prostate Cancer Early Detection Panel (2014 - 2014)

  • Reviewer "Journal of Urology" (2009 - 2015)

  • Reviewer "Frontiers in Science" (2009 - 2015)

  • Reviewer "Urology" (2009 - 2015)

  • Participant Washington Heights free prostate cancer education and screening clinic (2008 - 2008)

International Activity

  • Grand Round Presentation "Management of T1 Bladder Cancer" Brooklyn, NY, United States (2011 - 2011)

  • Annual Meeting, Society of Urologic Oncology "B7x is a seum marker for prostate cancer." Bethseda, MD, United States (2009 - 2009)

  • Annual Meeting, American Urological Association, "The bladder trigone is not a Wolffian duct remnant." San Francisco, CA, United States (2006 - 2006)

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Contact Info

Preston C. Sprenkle, MD
Patient Care Locations
Yale UrologySmilow Cancer Hospital at Yale - New Haven
35 Park Street, Ste 4th Floor Multispecialty Care Center

New Haven, CT 06511
VA Connecticut Healthcare
950 Campbell Avenue

West Haven, CT 06516
Mailing Address
PO Box 208058
New Haven, CT 06520-8058

Curriculum Vitae