Douglas E Brash PhD

Senior Research Scientist in Therapeutic Radiology and in Dermatology and Clinical Professor of Therapeutic Radiology

Departments & Organizations

Office of Student ResearchRadiobiology & RadiotherapyDermatology: Skin Diseases Research Center, Yale | Therapeutic Radiology/Radiation Oncology: RadiobiologyRadiobiology and Radiotherapy

Research Interests

Ultraviolet Light; Skin Cancer more...


  • B.S., University of Illinois, 1973
  • Ph.D., Ohio State University, 1979

Selected Publications

  • Premi, S, Wallisch, S, Mano, CM, Weiner, AB, Bacchiocchi, A, Wakamatsu, K, Bechara, EJH, Halaban, R, Douki, T, and Brash, DE. Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure. Science 347:842-7, 2015.
  • Rochette, PJ and Brash, DE. Human telomeres are hypersensitive to UV-induced DNA damage and refractory to repair. PLoS Genetics 6 (e1000926): 1-13, 2010.
  • Klein, AM, Brash, DE, Jones, PH, and Simons, BD. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UVB during preneoplasia. Proc. Natl. Acad. Sci. USA. 107:270-275, 2010.



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