Edward Leonard Snyder MD

Professor of Laboratory Medicine; Associate Chair, Clinical Affairs (Therapeutic); Director, Apheresis/Transfusion Service; Director, Blood Bank; Director of Membership, Yale Cancer Center; Editor, Lab News

Research Interests

Cytoskeleton; Health and Medicine; Membranes; Metabolism; Apheresis Technology; Pathogen Inactivation; Platelet Apoptosis; Platelet Storage Lesion Manufacturing Tissue Engineered Vascular Grafts for Pediatric Surgical Patients

Research Summary

Dr. Snyder's research relates to the broad field of Transfusion Medicine and, more specifically, Transfusion Oncology and Transfusion Immunobiology. His current research includes an on-going evaluation of the platelet storage lesion. This includes evaluation of alterations that occur in platelet metabolism during various storage conditions, in the platelet's cystoskeleton and in the mitochondria within platelets. Studies of the in vitro and in vivo aspects of platelet storage are an on-going effort in the laboratory. Dr. Snyder also has a long-term history of investigating the role of leukodepletion in blood components. Most recently, the laboratory has turned to the evaluation of new pathogen reduction technology. This includes the addition of various compounds to blood to remove known and potentially dangerous, as well as unknown, viral, bacterial, and protozoal contaminants in donated blood. The laboratory has a special expertise in radiolabeling human blood cells. The laboratory is currently performing clinical trials related to in vivo recovery and survivals using indium-111 and chromium-51 radiolabeled platelets and red cells, as well as Phase III trials for transfusion of pathogen-reduced blood components into patients. We are also involved in ongoing evaluations of clinical responses of patients to pheresis interventions for a variety of immunologic disorders. This is often done in conjunction with the evaluation of new apheresis machine hardware developed by a variety of corporations.

Dr. Snyder's current research also involves the seeding of biodegradable support structures (mandrils) for use with children with congenital heart disease. This is done in conjunction with Dr. Christopher Breuer.

Selected Publications

  • Tormey CA, Sweeney JD, Champion M, Pisciotto PT, Snyder EL, Wu YY. Analysis of transfusion reactions associated with pre-storage pooled platelet components. Transfusion (2008, in press)
  • Kirkiles-Smith NC, et al., Snyder, EL, et al. Development of a humanized mouse model to study the role of macrophages in allograft injury. Transplantation (2008, in press).
  • Snyder EL. Component therapy to cellular therapy and beyond- a Darwinian approach to transfusion medicine. Transfusion 2008; 48:2000-7.
  • Tormey CA, Snyder EL. Cooper DL. Mobilization, collection and transplantation of peripheral blood HPCs in a patient with multiple myeloma and hemoglobin SC disease. Transfusion 2008;48:1930-1933
  • Cancelas J, Bandarenko N, Snyder E, et al. Cryopreservation of AS-5 Collected RBCs in PVC or EVA bags, by the Closed ACP-215 System Allows Extended Storage for 14 Days Post Thawing. Transfusion 2007;47:680-6.
  • Murphy S, Snyder EL, Cable R, et al. Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia. An analysis of the SPRINT Trial of platelets photochemically treated with amotosalen HCL and ultraviolet A light. Transfusion 2006;46:24-33.
  • Eisenbarth S, Champion M, Snyder EL. Logistics of Platelet Concentrates. Vox Sang. 2007:

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