Tompkin's East 2
New Haven, CT 06520-8042
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Because the burden of misdiagnosed brain disorders and diseases is substantial, the Hyder lab is leading breakthroughs in quantitative and translational imaging technologies, based primarily on magnetic resonance methods, to visualize molecular processes of function and dysfunction at the laminar level of the mammalian brain.
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High resolution functional imaging. In vivo examples of fMRI for different rodent sensory models, where the colored voxels overlaid on top of the gray anatomy reflect sensory-induced function revealed by BOLD contrast. Courtesy of Basavaraju G. Sanganahalli and Christopher J. Bailey.
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High resolution anatomical imaging. In vivo example of high resolution DTI in rodent brain, where the yellow, pink, and green colors represent respective directional dominance of fractional anisotropy of water diffusion to reflect tissue microstructure. Courtesy of Daniel Coman and Basavaraju G. Sanganahalli.
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High resolution molecular imaging. Based on a platform of an ultra-fast chemical shift imaging method called BIRDS, where we detect paramagnetically-shifted non-exchangeable protons from chelated lanthanide (or transition) metal ion probes, examples of high resolution temperature maps in rodent brain are shown. Data from Coman et al (2013) NMR Biomed. 26:1589-1595.
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High resolution optical imaging of blood rheology. In vivo examples of laser speckle contrast leading to RBC velocity in rodent brain. The RBC velocity data are used to measure the rheological properties of BOLD contrast. Courtesy of Peter Herman.
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High resolution electrical imaging of local field potential (LFP) and multi-unit activity (MUA). In vivo example of a 6x6 electrode array recording of MUA and LFP in rodent brain during sensory stimulation. The arrows reveal spatial uncoupling between MUA and LFP which has relevance for physiological interpretation of BOLD contrast. Courtesy of Peter Herman.