Acquired Immunodeficiency Syndrome; Chronic Disease; Hepatitis; HIV; Neoplasms; Neoplasms by Site; Hepacivirus; Women's Health; Biostatistics
Public Health Interests
Biomarkers; Biostatistics; Cancer Epidemiology; Cancer genetics; Cancer screening; Cancer Survival; Chronic Conditions; Data analysis; Diabetes; Epidemiology Methods; Hepatitis; HIV/AIDS; Women's Health
Yale Institute for Global Health
Dr. Shebl current research involves investigating genetic and non-genetic determinants of hepatitis C virus spontaneous and drug induced clearance. In addition, Dr. Shebl is interested in examining the role of inflammation and infection in cancer risk. In the future, Dr. Shebl will focus on understanding cancer’s molecular bases, and identifying biomarkers for early cancer detection, especially for hepatocellular carcinoma. In addition she will investigate the host immune response in individuals infected with hepatitis C virus.
Specialized Terms: HCV response to treatment; Natural history of HCV infection; Immune response; Infection-related cancer; Cancer epidemiology; Cancer immunology; Inflammation; Research methodology
Extensive Research Description
The overarching goal of Dr. Shebl research is to characterize the role of infections, inflammation, and immunosuppression in cancer etiology so that this knowledge may be translated into strategies for prevention, early detection, and new treatment targets. Dr. Shebl have developed a portfolio of research projects in two major areas: (i) Infection, inflammation and immunosuppression in cancer etiology, and (ii) Hepatitis C virus: epidemiology, determinants of clearance, response to treatment, and cancer risk.Infections and inflammation are recognized as major contributors to cancer risk and might account for approximately 20-25% of cancer cases. Thus, Dr. Shebl research focuses on elucidating the role of infection and inflammation in cancer. Therefore, she utilized several strategies including; studying cancer in populations that are at high risk of infection, inflammation and immunosuppression such as individuals infected with human immunodeficiency virus and individuals with end-stage renal disease, studying inflammation associated conditions such as obesity, diabetes and metabolic syndrome, and finally utilizing direct measures of inflammation such as cytokines.
Chronic HCV infection is observed in approximately 70-80% of HCV infected cases. HCV infection is associated with many complications, as well as cancer. The association between HCV and liver cancer is well known, however, there is increasing evidence supporting the interplay between HCV and the immune response, which might influence not only liver cancer risk but other cancers as well. This notion underscores the importance of immune stimulation in carcinogenesis, which is an area of growing interest. Therefore, Dr. Shebl utilized several strategies to approach these questions including; studying the genetic and non-genetic determinants of spontaneous clearance, and response to treatment, and identifying HCV-related cancer risk including hepatic and extrahepatic cancer sites
IL28B-rs12979860 Genotype and Spontaneous Clearance of Hepatitis C Virus in a Multi-Ethnic Cohort of Injection Drug Users:Evidence for a Supra-Additive Association.
Shebl FM, Pfeiffer RM, Edlin BR, et al. IL28B-rs12979860 Genotype and Spontaneous Clearance of Hepatitis C Virus in a Multi-Ethnic Cohort of Injection Drug Users:Evidence for a Supra-Additive Association. J Infect dis (in press) PMCID: PMC Journal – In Process
Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China.
Shebl FM, Andreotti G, Meyer TE, et al. Metabolic syndrome and insulin resistance in relation to biliary tract cancer and stone risks: a population-based study in Shanghai, China. Br J Cancer. 2011 Sep 13. [Epub ahead of print] PMCID: PMC Journal – In Process
Increased Levels of Circulating Cytokines with HIV-Related Immunosuppression.
Shebl FM, Yu K, Landgren O, Goedert JJ, Rabkin CS. Increased Levels of Circulating Cytokines with HIV-Related Immunosuppression. AIDS Res Hum Retroviruses. 2011 Sep 30. [Epub ahead of print] PMCID: PMC Journal – In Process
The Relationship between DNA Methylation and Telomere Length in Dyskeratosis Congenita.
Gadalla SM, Katki HA, Shebl FM, et al. The Relationship between DNA Methylation and Telomere Length in Dyskeratosis Congenita. Aging Cell. 2011 Oct 8. [Epub ahead of print] PMCID: PMC Journal – In Process Shebl FM, Dollard SC, Pfeiffer RM, Biryahwaho B, Amin MM, Munuo SS, Hladik W, Parsons R, Graubard BI, Mbulaiteye SM. Human herpesvirus 8 seropositivity among sexually active adults in Uganda. PLoS One. 2011;6(6):e21286. Epub 2011 Jun 21. PMCID:PMC3119672
In the Absence of HCV Infection, Interferon Stimulated Gene Expression in Liver is Not Associated with IL28B Genotype.
Shebl FM, Maeder D, Shao Y et al. In the Absence of HCV Infection, Interferon Stimulated Gene Expression in Liver is Not Associated with IL28B Genotype. Gastroenterology. 2010 Oct;139(4):1422-4. Epub 2010 Aug 25
Full List of PubMed Publications
- Cunningham SD, Magriples U, Thomas JL, Kozhimannil KB, Herrera C, Barrette E, Shebl FM, Ickovics JR: Association Between Maternal Comorbidities and Emergency Department Use Among a National Sample of Commercially Insured Pregnant Women. Acad Emerg Med. 2017 Aug; 2017 Jun 12. PMID: 28471532
- Kollannoor-Samuel G, Shebl FM, Hawley NL, Pérez-Escamilla R: Nutrition label use is associated with lower longer-term diabetes risk in US adults. Am J Clin Nutr. 2017 May; 2017 Mar 29. PMID: 28356273
- Pardo CA, Farmer CA, Thurm A, Shebl FM, Ilieva J, Kalra S, Swedo S: Serum and cerebrospinal fluid immune mediators in children with autistic disorder: a longitudinal study. Mol Autism. 2017; 2017 Jan 5. PMID: 28070266
- Kollannoor-Samuel G, Shebl FM, Hawley NL, Pérez-Escamilla R: Nutrition facts panel use is associated with higher diet quality and lower glycated hemoglobin concentrations in US adults with undiagnosed prediabetes. Am J Clin Nutr. 2016 Dec; 2016 Oct 26. PMID: 27797707
- Yang B, Shebl FM, Sternberg LR, Warner AC, Kleiner DE, Edelman DC, Gomez A, Dagnall CL, Hicks BD, Altekruse SF, Hernandez BY, Lynch CF, Meltzer PS, McGlynn KA: Telomere Length and Survival of Patients with Hepatocellular Carcinoma in the United States. PLoS One. 2016; 2016 Nov 23. PMID: 27880792
- Kollannoor-Samuel G, Shebl FM, Segura-Pérez S, Chhabra J, Vega-López S, Pérez-Escamilla R: Effects of Food Label Use on Diet Quality and Glycemic Control Among Latinos With Type 2 Diabetes in a Community Health Worker-Supported Intervention. Am J Public Health. 2016 Jun; 2016 Apr 14. PMID: 27077337
- Troche JR, Mayne ST, Freedman ND, Shebl FM, Guertin KA, Cross AJ, Abnet CC: Alcohol Consumption-Related Metabolites in Relation to Colorectal Cancer and Adenoma: Two Case-Control Studies Using Serum Biomarkers. PLoS One. 2016; 2016 Mar 11. PMID: 26967509
- Loftfield E, Shiels MS, Graubard BI, Katki HA, Chaturvedi AK, Trabert B, Pinto LA, Kemp TJ, Shebl FM, Mayne ST, Wentzensen N, Purdue MP, Hildesheim A, Sinha R, Freedman ND: Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers. Cancer Epidemiol Biomarkers Prev. 2015 Jul; 2015 May 21. PMID: 25999212
- Pérez-Escamilla R, Damio G, Chhabra J, Fernandez ML, Segura-Pérez S, Vega-López S, Kollannor-Samuel G, Calle M, Shebl FM, D'Agostino D: Impact of a community health workers-led structured program on blood glucose control among latinos with type 2 diabetes: the DIALBEST trial. Diabetes Care. 2015 Feb; 2014 Aug 14. PMID: 25125508
- Loftfield E, Freedman ND, Graubard BI, Hollenbeck AR, Shebl FM, Mayne ST, Sinha R: Coffee drinking and cutaneous melanoma risk in the NIH-AARP diet and health study. J Natl Cancer Inst. 2015 Feb; 2015 Jan 20. PMID: 25604135
- Jefee-Bahloul H, Moustafa MK, Shebl FM, Barkil-Oteo A: Pilot assessment and survey of Syrian refugees' psychological stress and openness to referral for telepsychiatry (PASSPORT Study). Telemed J E Health. 2014 Oct; 2014 Sep 4. PMID: 25188281
- Shebl FM, Emmanuel B, Bunts L, Biryahwaho B, Kiruthu C, Huang ML, Pfeiffer RM, Casper C, Mbulaiteye SM: Population-based assessment of kaposi sarcoma-associated herpesvirus DNA in plasma among Ugandans. J Med Virol. 2013 Sep. PMID: 23852686
- Shebl FM, Warren JL, Eggers PW, Engels EA: Cancer risk among elderly persons with end-stage renal disease: a population-based case-control study. BMC Nephrol. 2012 Jul 26; 2012 Jul 26. PMID: 22834953
- Shebl FM, El-Kamary SS, Shardell M, Langenberg P, Dorgham LS, Maguire JH, Magder LS: Estimating incidence rates with misclassified disease status: a likelihood-based approach, with application to hepatitis C virus. Int J Infect Dis. 2012 Jul; 2012 Apr 28. PMID: 22543295