Gerald S Shadel PhD

Professor of Pathology and of Genetics; Director, Pathology Research

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Cancer Genetics & Genomics

Integrative Cell Signaling & Neurobiology of Metabolism (ICSNM)

Pathology: Shadel Lab | ExPath


Research Interests

Mitochondria; Mitochondrial Genetics and Biogenesis; Mitochondrial Dysfunction in Human Disease and Aging; Mechanisms of mtDNA Transcription and Mitochondrial Translation; Signaling Pathways that Sense and Control Mitochondrial Function; Cancer; Immune System Signaling more...


  • B.S., University of Nevada, Las Vegas, 1986
  • Ph.D., Texas A & M University, 1991

Selected Publications

  • Raimundo N, Song L, Shutt TE, Mckay SE, Cotney J, Guan M-X, Gilliland TC, Hohuan, D, Santos-Sacchi J & Shadel GS. (2012) Mitochondrial Stress engages E2F1 apoptotic signaling to cause deafness. Cell, 148:716-726.
  • Woo DK, Green PD, Santos JH, D’Souza AD, Walther Z, Martin, WD, Christian BE, Chandel NS & Shadel GS. (2012) Mitochondrial Genome Instability and ROS enhance tumorigenesis in APCMin/+ mice. Am J Pathology. 180:24-31.
  • D’Souza AD, Parish IA, Krause DS, Kaech SM, & Shadel GS. (2012) Reducing Mitochondrial ROS Improves disease-related pathology in a mouse model of Ataxia-telangiectasia. Molecular Therapy, September 25.



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