Hakryul Jo Ph.D.

Associate Research Scientist in Epidemiology (Environmental Health)

Natural and synthetic chemicals; Cancer; Age-related macular degeneration

Jo H*, Mondal, Subhanjan M*, Tan D, Nagata E, Sharma AK, Hou Q, Shanmugasundaram K, Tung J, Tejeda AO, Man H, Rigby AC, and Luo HR. Small molecule-induced cytosolic activation of Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 (in press) (*Equal contribution)
Jo H* and Luo HR*. Exploiting Effectors of Rac GTPase. Chem Biol. 2012 Feb 24;19 (2):169-71 (*Corresponding author)
Jo H, Lo P, Li Y, Loison F,Green S,Wang J, Silberstein LE, Ye K, Chen H, and Luo HR. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6486-91
Jo H, Loison F, Hattori H, Silberstein LE, Yu H, Luo HR. Natural product Celastrol destabilizes tubulin heterodimer and facilitates mitotic cell death triggered by microtubule-targeting anti-cancer drugs. PLoS One. 2010 Apr 23;5(4):e10318.
Jo H., Jia Y. Subramanian KK. Hattori H, Luo HR Cancer cell-derived clusterin modulates the phosphatidylinositol 3'-kinase-Akt pathway through attenuation of insulin-like growth factor 1 during serum deprivation. Mol Cell Biol. 2008 Jul;28(13):4285-99.
Hattori H, Subramanian KK, Sakai J, Jia Y, Li Y, Porter TF, Loison F, Sarraj B, Kasorn A, Jo H, Blanchard C, Zirkle D, McDonald D, Pai SY, Serhan CN, Luo HR. Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3546-51.