Jose Costa, FACP

Professor of Pathology, of Medicine (Medical Oncology) and of Orthopaedics and Rehabilitation; Director, Translational Diagnostics; Director, Musculoskeletal Tumor Program

Research Organizations

Cancer Center, Yale: Cancer Genetics & Genomics

Gene Regulation and Functional Genomics

Molecular Diagnostics

Pathology

Research Summary

I am interested in understanding the forces driving tumor formation and tumor progression. Using clues from clinical observation, experimental models and in silico simulations, I formulate hypotheses that can then be tested either in the laboratory or in the clinic. For example, the theory that carcinogenesis is a micro-evolutionary process best described by metapopulation dynamics provides a framework for understanding the origins of tumor heterogeneity and explains the reason for the long term failures of some therapies. It also demonstrates how intermediate disturbance can favor the emergence and progression of tumors without significant increase in mutational rate. Theory also suggests that inhibiting the so-called capacitors of evolution may be a useful intervention to increase the therapeutic effect of some of the anticancer agents used in the clinic.

Selected Publications

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Contact Info

Jose Costa, FACP
Patient Care Location
Yale PathologyYale-New Haven Hospital
20 York Street, Ste East Pavilion 2-631

New Haven, CT 06510
Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 254A

New Haven, CT 06510
Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Community of Science (COS) Database

Department of Pathology Homepage

Residency Training Program

Surgical Pathology

Yale Cancer Center