Research & Education | Members | Signal Transduction

Program Members

Co-Leaders

Petrylak, Daniel

Clinical Interests:genitourinary cancer; prostate cancer; clinical trials for men with prostate and bladder cancer.

Office:(203) 737-8076
Appt:(203) 200-4822

Members

Bennett, Anton

Research Interests:Signal transduction; Protein tyrosine phosphatases; Cancer; Diabetes; Obesity; Muscle stem cells; Muscular dystrophy

Office:(203) 737-2441
Lab:(203) 785-4395

Boggon, Titus

Research Interests:Structural biology of signal transduction

Office:(203) 785-2943
Lab:(203) 785-7274

Calderwood, David

Research Interests:Integrin; Cell adhesion; Cell migration; Cytoskeleton; Structural biology

Office:(203) 737-2311
Lab:(203) 785-2871

Cantley, Lloyd

Research Interests:Nephrology; physiology and integrative medical biology; epithelial cell migration and morphogenesis; epithelial cell adhesion; migration; branching tubulogenesis

Office:(203) 785-4186
Lab:(203) 785-7111

De Camilli, Pietro

Research Interests:Synapses; exocytosis; endocytosis; membranes; clathrin; dynamin; phosphoinositides; Lowe syndrome; BAR proteins; neurodegeneration

Office:(203) 737-4461
Lab:(203) 737-4457

DiGiovanna, Michael

Research Interests:Breast cancer; HER-2/neu/ErbB-2; IGF1 receptor; EGF receptor; Growth factor receptor tyrosine protein kinases in malignancy; estrogen receptor, signal transduction

Office:(203) 785-2360
Lab:(203) 785-5365
Appt:(203) 200-2328

Research Interests:Gastric Acid Secretion; Colonic Fluid Transport; Renal Physiology; Intracellular Ion Activity Measurements; Calcium Sensing Receptor; Diarrheal disease, electrophysiology; CFTR; AMPKinase volume regulation

Office:(203) 737-4152
Lab:(203) 737-1485

Greco, Valentina

Research Interests:Organ regeneration in vertebrate systems; Stem cells; Stem cell niche organization; cancer

Grutzendler, Jaime

Research Interests:Two-photon microscopy; Neurodegeneration; Alzheimer's; Blood-brain barrier; Microvasculature; Synapses; Neuroinflammation; Microglia; Astrocyte; Endothelium, myelin imaging

Lab:(203) 737-3514
Appt:(203) 737-8859

Hochstrasser, Mark

Research Interests:Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin

Horsley, Valerie

Insogna, Karl

Research Interests:Role of dietary protein in skeletal metabolism; Factors that lead to skeletal disease in adult patients with X-linked hypophosphatemic rickets; Cellular mechanisms of PTH-induced bone resorption and bone anabolism; Effects of CSF1 in mature osteoclasts

Office:(203) 737-2871
Lab:(203) 737-2871
Appt:(203) 737-1058

Jo, Hakryul

Research Interests:Natural and synthetic chemicals; Cancer; Age-related macular degeneration

Kibbey, Richard

Research Interests:Mechanisms of insulin secretion by beta-cells; pathogenesis of beta-cell exhaustion in Type 2 Diabetes Mellitus; mitochondria

Office:(203) 737-4055
Appt:(203) 432-0038

Koleske, Anthony

Research Interests:Neuronal morphogenesis and degeneration; stress; schizophrenia; cell migration; cancer; metastasis; adhesion receptors

Office:(203) 785-5624
Lab:(203) 785-5631

Krauthammer, Michael

Research Interests:Molecular interaction networks: computational analysis, pathway discovery, knowledge representation; Statistical modeling and analysis; Text mining in biology: term identification, information extraction

Madri, Joseph

Research Interests:Connective tissue disorders; Cell-Matrix and Cell-Cell Interactions; Integrin-Mediated Signaling; Cardio-vascular development; Angiogenesis and Vascular Biology; inflammation; T-cell-Endothelial cell interactions

Office:(203) 785-2763
Appt:(203) 785-2783

Maihle, Nita

Research Interests:Cancer; Women's cancers; Diagnostics; Theragnostics; Biotherapeutics; Precision/personalized medicine, signal transduction; EGFR/ERBB/HER-driven adult solid tumors

Office:(203) 785-5212
Lab:(203) 737-1385

Min, Wang

Research Interests:Inflammation; Angiogenesis/lymphangiogenesis; Atherosclerosis; Transplant rejection; Tumor microenvironment and metastasis

Morrow, Jon

Research Interests:Hemolytic Disease; Degenerative Brain Disease; spectrin; Autopsy Pathology; Renal Pathology; Medical Informatics; Computer Aided Instruction (CAI); Telepathology

Office:(203) 785-3624
Lab:(203) 785-2771
Appt:(203) 785-3624

Nguyen, Don

Research Interests:Metastasis; Lung cancer; Cancer genomics; Tumor microenvironment

Office:(203) 737-4514

Politi, Katerina

Research Interests:Cancer biology; Mouse models of lung cancer; Epidermal Growth Factor Receptor; ERBB Receptor family; Targeted therapy

Rimm, David

Research Interests:Quantitative Pathology; Cancer Tissue Biomarkers; Melanoma; Breast Cancer; Cell-cell adhesion in cancer; Translation of molecular techniques to diagnostic cytopathology; General Cytopathology; Immunohistochemistry; thyroid pathology

Office:(203) 737-4204
Appt:(203) 737-4204

Schlessinger, Joseph

Research Interests:Growth factor receptors; Intracellular signaling pathways;protein kinases; phosphorylation; SH2, SH3 and other protein modules involved in signal transduction; drug discovery