Steven H Kleinstein PhD

Associate Professor of Pathology and of Immunobiology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Computational Biology and Bioinformatics | Immunology

Office of Student ResearchMedical Informatics, Yale Center forCancer ImmunologyImmunobiology: Lymphocyte Development; HTIPathology: Informatics Program; Kleinstein Lab; ExPath

Research Interests

Computational immunology; Systems biology; Bioinformatics; Disease/tissue/pathway/process modeling and simulation; B cell immunoglobulin repertoire analysis; Influenza more...


  • Ph.D., Princeton University, 2002

Selected Publications

  • Stern JNH*, Yaari G*, Vander Heiden JA*, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH**, Hafler DA** and O’Connor KC**. B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes. Science Translational Medicine. 2014. Aug 6;6(248):248ra107. doi:10.1126/scitranslmed.3008879. PMID: 25100741.
  • Vander Heiden JA*, Yaari G*, Uduman M, Stern JNH, O’Connor KC, Hafler DA, Vigneault F and Kleinstein SH. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics. 2014. Jul 1;30(13):1930-2. doi: 10.1093/bioinformatics/btu138. PMCID: PMC4071206.
  • Yaari G, Vander Heiden J, Uduman M, Gadala-Maria D, Gupta N, Stern J.N.H., O’Connor KC, Hafler DA, Laserson U, Vigneault F and Kleinstein SH. Models of somatic hypermutation targeting and substitution based on synonymous mutations from high-throughput Immunoglobulin sequencing data. Frontiers in Immunology. 2013. 2013 Nov 15;4:358. doi: 10.3389/fimmu.2013.00358. PMCID: PMC3828525.



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