Titus J. Boggon, PhD

Associate Professor of Pharmacology and of Molecular Biophysics and Biochemistry

Research Interests

Molecular Biology; Signal Transduction; Hemangioma, Cavernous, Central Nervous System

Research Organizations

Signal Transduction

Signal Transduction

Structural Biology

Research Summary

The Boggon lab is interested in using structural biology approaches to help understand functional alterations that impact human disease. Specific areas of interest are briefly described below. Please also see the lab website: www.boggonlab.org

Cerebral Cavernous Malformations

Cerebral cavernous malformations (CCM) disease has a prevalence of 0.1-0.5% in the human population and is an important cause of hemorrhagic stroke. Between 10 and 50% of CCM cases are associated with inherited autosomal-dominant mutations in three genes, KRIT1 (CCM1),CCM2 and CCM3 (PDCD10). These mutations result in loss-of-function of the protein products of these genes (KRIT1, CCM2 and CCM3) and result in destabilized vascular endothelial cell-cell interactions and CCM lesions. We are studying CCM3, CCM2 and KRIT1 using a structure-directed functional approach and have determined the first crystal structures of each of these proteins.

Integrin signaling

Integrins are transmembrane receptors that play essential roles during development, tissue formation, hemostasis, and in response to injury and infection. We are particularly interested in the integrin-linked kinase, pinch, parvin (IPP) complex, a hub in integrin-actin and integrin-signaling networks. The IPP complex has critical roles in anchorage-dependent cell growth and survival, cell cycle progression, epithelial to mesenchymal transition, cell motility, contractility and early development.

Rho GTPase signaling cascades

Rho family GTPases are critical regulators of actin dynamics and are important for cell proliferation, apoptosis, cell-cycle and cell adhesion. We are interested in understanding the structural biology of the signaling cascades which are regulated by Rho GTPases and the ways that these pathways are altered in disease, especially cancer.

We are also investigating regulation mechanisms for downstream Rho-family effector molecules, and have discovered that the type II p21-activated kinases are regulated by pseudosubstrate autoinhibition.

Specialized Terms: Structural biology of signal transduction

Selected Publications

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Contact Info

Titus J. Boggon, PhD
Lab Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste Suite 302

New Haven, CT 06510
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Office Location
Sterling Hall of Medicine, B-Wing
333 Cedar Street, Ste SHM B316A

New Haven, CT 06510
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Mailing Address
Department of PharmacologyPO Box 208066
333 Cedar Street

New Haven, CT 06520-8066

Boggon Lab

Research Image 1

Structure of integrin-linked kinase ankyrin repeat domain and PINCH1 LIM1 domain

Research Image 2

Structure of CCM3