Walther H Mothes, PhD

Associate Professor of Microbial Pathogenesis

Research Interests

Cell Biology; HIV; Immune System; Retroviridae; Biochemical Processes

Research Organizations


Molecular Virology: Virology laboratories

Virus and Other Infection-associated Cancers

Research Summary

Dr. Mothes’ laboratory is interested in various aspects of viral spread and pathogenesis of HIV-1 and other retroviruses. Retroviruses can efficiently spread from cell to cell through contact zones, called virological and infectious synapses. The Mothes lab has contributed to this process by directly visualizing how cell-cell contracts between infected and uninfected cells form, virus assembly is directed towards cell-cell contact sites and viruses are actively transferred to infect neighboring cells. A major current interest of the laboratory is to monitor viral spread and aspects of retroviral pathogenesis directly in living animals using multi-photon laser scanning microscopy. The laboratory is also applying single molecule imaging to understand how conformational events in the HIV-1 envelope protein lead to fusion between viral and cellular membranes. A detailed understanding of these processes will permit the rational design of vaccines and antiviral therapies that prevent virus spreading and the infection of new cells.

Specialized Terms: cell biology; retroviral replication; retroviruses; immune; viral biology; genetic; biochemical; cell imaging; Viral entry and exit; Retroviruses including HIV

Selected Publications

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Contact Info

Walther H Mothes, PhD
Mailing Address
Boyer Center for Molecular MedicineSection of Microbial Pathogenesis
295 Congress Avenue

New Haven, CT 06519

Curriculum Vitae

The Mothes Laboratory