Demetrios Braddock, MD, PhD

Associate Professor of Pathology; Medical Director, Precipio Diagnostics

Research Interests

Osteoarthropathy, Primary Hypertrophic; Pathology; Pseudoxanthoma Elasticum; Sickle Cell Trait; Rare Diseases; Vascular Calcification

Research Organizations

Pathology: Braddock Lab | Pathology Research

Cancer Center: Genomics, Genetics, and Epigenetics

Discovery to Cure Internship

Gene Regulation and Functional Genomics

Structural Biology

Vascular Biology and Therapeutics Program

Office of Cooperative Research

Research Summary

  • Structural biology of protein complexes implicated in the pathogenesis of cancer
  • Genetic transcription

Specialized Terms; Structural biology; Hematopathology; Genitourinary Pathology

Extensive Research Description

My group is primarily interested in biochemical and structural aspects of oncogensis and blood disorders. We have recently described two endothelial enzymes within the brain vasculature that promote platelet aggregation by converting small molecule signals released from platelets into ADP. Polymorphisms in one of these enzymes has recently been discovered to confer stroke protection to pediatric sickle cell patients, indicated the centrality of these enzymes in the pathophysiology of stroke.

Selected Publications

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Contact Info

Demetrios Braddock, MD, PhD
Patient Care Locations
Yale PathologyYale-New Haven Hospital
20 York Street

New Haven, CT 06510
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Lauder Hall
310 Cedar Street, Rm LH 404A

New Haven, CT 06510
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Office Location
Department of PathologyLauder Hall
310 Cedar Street, Rm LH 404A

New Haven, CT 06510
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Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Curriculum Vitae