James Michael McGrath MD

Research Scientist in Comparative Medicine, in Genetics and in Pediatrics

Research Interests

Developmental Genetics; Genetic Imprinting; Embryogenesis; Spermatogenesis

Research Summary

Genetic imprinting; mouse embryo development; embryonic stem cells; gene knockouts; embryo cryopreservation; sperm cryopreservation; cloning; nuclear transfer; left right development; Beckwith Weidemann syndrome; genomic imprinting; nuclear transfer; embryonic stem cell derivation; gene knockouts in embryonic stem cells.

Selected Publications

  • Lin ZP, Zhu YL, Johnson DR, Rice KP, Nottoli T, Hains BC, McGrath J, Waxman SG, Sartorelli AC (2008) Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Mol Pharmacol. 73(1):243-51.
  • Shaikh TH, O'Connor RJ, Pierpont ME, McGrath J, Hacker AM, Nimmakayalu M, Geiger E, Emanuel BS, Saitta SC (2007) Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms. Genome Res. 17(4):482-91.
  • Hallaq H, Pinter E, Enciso J, McGrath J, Zeiss C, Brueckner M, Madri J, Jacobs HC, Wilson CM, Vasavada H, Jiang X, Bogue CW (2004) A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels. Development. 131(20):5197-209.
  • McGrath J, Somlo S, Makova S, Tian X, Brueckner M (2003) Two populations of node monocilia initiate left-right asymmetry in the mouse. Cell. 114(1):61-73.
  • McGrath J, Solter D (1984) Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell. 37(1):179-83.

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