Samuel G. Katz, MD, PhD

Assistant Professor of Pathology

Research Interests

Leukemia; Lymphoma; Stem Cells; Cell Death; Apoptosis; Genes, bcl-2; Endoplasmic Reticulum Stress

Research Organizations

Cancer Center, Yale: Cancer Genetics & Genomics

Pathology: Katz Lab

Research Summary

The goal of the Katz laboratory is to selectively control the cell death machinery for therapeutic benefit. Toward that end a multidisciplinary approach is applied to understand how mammalian cells are conditioned to expire, and how mutations in essential apoptotic regulators lead to developmental defects or malignancy. In particular, BCL-2 family proteins are vital regulators of mitochondrial integrity and have been implicated in the development, maintenance and chemoresistance of numerous cancers. While the basic mode of BCL-2 family action is established, how this pathway is integrated in the context of various cellular programs, including alternate survival and death pathways, is not nearly as well understood.

Thus, we focus on:

  1. severe apoptotic blockades in cancer stem cells;
  2. loss of pro-apoptotic BCL-2 family members in mantle cell lymphoma as well as other cancers; and
  3. the mechanism of key understudied family members.

Selected Publications

Edit this profile

Contact Info

Samuel G. Katz, MD, PhD
Patient Care Location
Yale PathologyYale-New Haven Hospital
20 York Street, Ste East Pavilion 2608

New Haven, CT 06510
Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 127A

New Haven, CT 06510
Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06510-8023

Katz Lab