Herbert Yu, MD, PhD

Research Interests

Breast Neoplasms; Liver Neoplasms; Neoplasms; Ovarian Neoplasms; Uterine Neoplasms; Molecular Epidemiology; Gene-Environment Interaction

Research Organizations

Cancer Prevention and Control

Cancer Prevention and Control

School of Public Health

Research Summary

Professor Yu's research interest is in molecular epidemiology of chronic diseases with focus on cancer etiology and tumor progression in relation to genetic variations, epigenetic changes, and gene-environment interaction. His recent work includes studies of molecular mechanisms underlying the connection of breast and endometrial cancers to lifestyle and energy balance, as well as DNA methylation in tumor suppressor genes and DNA repair genes and its role in aging and cancer prognosis. The effect of mitogenic growth factors on cancer development and the interplay of these growth factors with environment and lifestyle factors are also part of the research focus in Professor Yu's laboratory. Professor Yu also conducts clinical epidemiological studies to assess molecular and genetic markers for cancer diagnosis and prognosis. Professor Yu's laboratory serves as Molecular Epidemiology Shared Resource for the Yale Cancer Center.

Specialized Terms: Gene-environment interaction in cancer development and progression; Energy balance and mitogenic growth factors in cancer; Lifestyle's impact on epigenetic regulation in relation to cancer risk and prognosis; Molecular markers for cancer detection, prognosis and treatment

Extensive Research Description

  • Role of Genetic and Lifestyle Interplay in Uterus Cancer
  • Molecular Characterization of the Insulin-like Growth Factor System in Breast Cancer and Ovarian Cancer and its Association with Tumor Progression
  • Case-control Study of Pancreatic Cancer Etiologic Factors
  • DNA Methylation in Cancer Risk and Progression
  • Case-control study of Liver Cancer
  • GWAS on Endometrial Cancer

Selected Publications

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Contact Info

Herbert Yu, MD, PhD
Office Location
Laboratory of Epidemiology and Public Health
60 College Street, Ste 700

New Haven, CT 06510
Mailing Address
Yale School of Public HealthPO Box 208034
60 College Street

New Haven, CT 06520-8034