Joseph N Contessa MD, PhD

Assistant Professor of Therapeutic Radiology and of Pharmacology

Research Interests

Receptor tyrosine kinase signaling; Adaptive responses of tumor cells to ionizing radiation; Protein N-linked glycosylation; High throughput screens for novel therapeutic agents; Biologic markers for radiation response

Current Projects

Therapeutic approaches for the treatment of EGFR and FGFR addicted lung cancer

Radiosensitization of malignant gliomas

Novel small molecule inhibitors of N-linked glycosylation

Molecular Imaging of the Epidermal Growth Factor Receptor

Drug Discovery and High Throughput Screening

Targeted therapy for head and neck squamous cell carcinoma

Selected Publications

  • Johung KL, Yao X, Li F, Yu JB, Gettinger SN, Goldberg S, Decker RH, Hess JA, Chiang VL, Contessa JN. A Clinical Model for Identifying Radiosensitive Tumor Genotypesin Non-Small Cell Lung Cancer.Clin Cancer Res. 2013 Jul 29. [Epub ahead of print]
  • Khan AP, Contessa JN, Nyati MK, Ross BD, Rehemtulla A. Molecular imaging of epidermal growth factor receptor kinase activity. Anal Biochem. 2011 Oct 1;417(1):57-64.
  • Contessa JN, Bhojani MS, Freeze HH, Ross BD, Rehemtulla A, Lawrence TS. Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapy. Clin Cancer Res. 2010 Jun 15;16(12):3205-14.
  • Contessa JN, Bhojani MS, Freeze HH, Rehemtulla A, Lawrence TS. Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cells. Cancer Res. 2008 May 15;68(10):3803-9.
  • Contessa JN, Hampton J, Lammering G, Mikkelsen RB, Dent P, Valerie K, Schmidt-Ullrich RK. Ionizing radiation activates Erb-B receptor dependent Akt and p70 S6 kinase signaling in carcinoma cells. Oncogene. 2002 Jun 6;21(25):4032-41.
  • Contessa JN, Abell A, Mikkelsen RB, Valerie K, Schmidt-Ullrich RK. Compensatory ErbB3/c-Src signaling enhances carcinoma cell survival to ionizing radiation. Breast Cancer Res Treat. 2006 Jan;95(1):17-27
  • Contessa JN, Reardon DB, Todd D, Dent P, Mikkelsen RB, Valerie K, Bowers GD, Schmidt-Ullrich RK. The inducible expression of dominant-negative epidermal growth factor receptor-CD533 results in radiosensitization of human mammary carcinoma cells. Clin Cancer Res. 1999 Feb;5(2):405-11.

Edit Profile