Barbara E Ehrlich, PhD

Professor of Pharmacology and of Cellular And Molecular Physiology

Research Interests

Calcium; Polycystic Kidney Diseases; Pharmacology; Physiology; Hermeneutics

Research Organizations

Cellular & Molecular Physiology: Neurobiology and Physiology of Synapses

Center for Polycystic Kidney Disease Research

Developmental Therapeutics

Interdepartmental Neuroscience Program

Research Summary

The Laboratory of Molecular Hermeneutics is interested in how cells regulate their intracellular calcium concentration. Cells use changes in calcium as a trigger for many cellular events, including cell growth, secretion, contraction, and neurotransmission. We have focused on one aspect of this process, the release of calcium from intracellular stores. We use calcium imaging combined with electrophysiological, biochemical, and molecular techniques to study the classes of calcium release channels known to exist inside virtually all cells: the InsP3-gated channel, the ryanodine receptor, and polycystin-2. Our first goal is to understand the basic question: how is the function of these channels regulated. Our second goal is to use the answers to the first question to understand the loss of calcium regulation observed in disease states as seen in cells from patients with polycystic kidney disease or leading to drug-induced neuropathy. We hypothesize that these abnormalities in function are consequences, at least in part, of altered intracellular calcium homeostasis and that our studies will lead to suitable treatment regimens.

Specialized Terms: Intracellular calcium regulation

Selected Publications

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Contact Info

Barbara E Ehrlich, PhD
Mailing Address
PO Box 208066
333 Cedar Street

New Haven, CT 06520-8066

Ehrlich Lab Website

Ehrlich Pubmed Bibliography

Journal of General Physiology Profile