David Adam Spiegel

Professor of Chemistry

Research Interests

Research Summary

The Spiegel Laboratory works in the area of “Synthetic Immunology,” which integrates synthetic chemistry, immunology, and cell biology toward the development of systems capable of controlling and/or creating human immunity. In particular, the lab has developed a class of antibody-recruiting small molecules (ARMs) that are capable of enhancing recognition of diverse pathogens by the human immune system. We have successfully employed this approach in targeting both HIV and prostate cancer, and are currently expanding its scope toward other diseases as well. Other areas of interest include re-engineering bacteria to perform complex immunological tasks, and investigations into advanced glycation end-products (AGEs), a poorly understood class of immunomodulatory post-translational modifications of proteins.

Selected Publications

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Contact Info

David Adam Spiegel
Lab Location
Class of 1954 Chemistry Research Building
275 Prospect Street, Ste #115, #117, #119, #121

New Haven, CT 06511
Office Location
Class of 1954 Chemistry Research Building
275 Prospect Street

New Haven, CT 06511

Curriculum Vitae

Spiegel Research Group