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Developmental Therapeutics 

Program Members

Co-Leaders

Anderson, Karen S

  • Office: (203) 785-4526
  • Lab: (203) 737-1527

Burtness, Barbara

Clinical Interests: head and neck cancers; esophagogastric cancers; non-melanoma skin cancer; thyroid cancer;

  • Office: (203) 737-7636
  • Appt: (203) 200-4622
     

Members

Abu-Khalaf, Maysa

Research Interests: Clinical trials evaluating novel agents for the treatment of breast; Ovarian and endometrial cancers; PI3K-mTOR inhibitors; HER-2 targeted therapies; Angiogenesis

  • Office: (203) 737-8309
  • Appt: (203) 200-2328

Anderson, Karen S

Research Interests: Enzyme function; Anti-viral agents

  • Office: (203) 785-4526
  • Lab: (203) 737-1527

Azodi, Masoud

Research Interests: Translational research; Clinical research; Gynecologic cancer

  • Office: (203) 785-4013
  • Appt: (203) 200-4176

Baehring, Joachim M

Research Interests: Molecular markers of cancer; Nervous system lymphoma

  • Appt: (203) 785-7284

Brandt, Debra Schwab

Research Interests: Clinical Protocol Investigator: Phase II trial of cytoxan, vincristine, and fludarabine in patients with CLL and primary and refractory low grade non-hodgkin’s lymphoma.

    Breaker, Ronald R

    Research Interests: non-coding RNA; riboswitches; ribozymes; catalytic DNA; RNA and evolution; antibiotics development

    • Office: (203) 432-9389
    • Lab: (203) 432-6554

    Burtness, Barbara

    Research Interests: EGFR expressed head and neck cancers.

    • Office: (203) 737-7636
    • Appt: (203) 200-4622

    Cha, Charles H

    Research Interests: Development of robotic and laparoscopic approaches for benign and malignant conditions of the liver, pancreas and stomach; Effects of angiogenesis on gastrointestinal malignancy; Gene silencing techniques to knockdown proliferation of hepatocellular carcinoma in vitro and in vivo; Diagnostic and therapeutic utility of angiogenic inhibitors for treatment of solid tumors; Clinical outcomes in surgery for sarcoma, hepatobiliary, gastric and esophageal malignancy

    • Appt: (203) 785-2380

    Chao, Herta H

    Research Interests: Prostate cancer; Androgen deprivation therapy; Cognitive function; Lung cancer; Phospho-inositol-3 kinase pathway as a drug target

      Cheng, Yung-Chi

      Research Interests: Cancer; Viral chemotherapy; Chinese herbs; Chinese medicine

      • Office: (203) 785-7118
      • Lab: (203) 785-7119

      Choi, Jennifer Nam

      Research Interests: Cutaneous side effects of chemotherapy and radiation; Melanoma treatment

      • Office: (203) 785-4092
      • Appt: (203) 789-1249

      Chung, Gina G

      • Office: (203) 785-2876
      • Appt: (203) 200-2328

      Crawford, Jason Michael

      Research Interests: Small molecule signaling; Antibiotic discovery & biosynthesis; Host-bacteria interactions; Bacterial secondary metabolism; Bacteria; Pathogen

        Crews, Craig M

        Research Interests: Limb regeneration; wound epidermis; blastema; natural product mode of action studies; angiogenesis; Wnt signaling; protein turnover; protein kinase regulation

        • Office: (203) 432-9364
        • Lab: (203) 432-6553

        Deshpande, Hari Anant

        Research Interests: Clinical trials in head and neck cancer; Sarcoma; Genitourinary (GU) cancer; Thyroid cancer; Endocrine cancers

        • Office: (203) 737-1600
        • Appt: (203) 200-4822

        DeVita, Vincent T, Jr

        Research Interests: Drug Resistance; Hodgkin's Disease; Lymphomas; Molecular Technology.

        • Office: (203) 737-1010

        Eder, Joseph Paul

        Research Interests: Phase I clinical trials; Cancer pharmacology; Angiogenesis

        • Office: (203) 737-6980
        • Appt: (203) 200-4422

        Ehrlich, Barbara E

        Research Interests: Intracellular calcium regulation

        • Office: (203) 737-1158
        • Lab: (203) 737-1158

        Ellman, Jonathan A

        Research Interests: proteases, phosphatases, inhibitors, C-H functionalization, asymmetric amine synthesis

          Engelman, Donald Max

          Research Interests: Helix Interactions; Lipid Bilayers; Membranes; Physical Biochemistry; Protein Folding; Proteins

            Farrell, James J

            Research Interests: Pancreatic Cancer Early Diagnosis; Pancreatic Cystic Neoplasms, Pancreatic Biomarkers, Personalized Medicine, Pancreatic Disease, Gastrointestinal Oncoloy

            • Office: (203) 785-6228
            • Lab: (203) 200-5083
            • Appt: (203) 200-5083

            Gettinger, Scott Nicholas

            Research Interests: Clinical trial design; Novel therapeutics; Radiosensitizers; Prognostic biomarkers

            • Appt: (203) 200-5864

            Goldberg, Sarah B

            Research Interests: Clinical trials; Translational research; Novel therapeutics; Personalized medicine

            • Office: (203) 785-7564
            • Appt: (203) 200-5864

            Gore, Steven D.

            Research Interests: Clinical trials for patients with leukemia and meylodysplastic syndromes with a focus on translational research. Mechanism behind the clinical activity of drugs which putatively target epigenetic dysregulation.

            • Office: (203) 737-7103
            • Appt: (203) 200-4363

            Ha, Ya

            Research Interests: Membrane protein; X-ray crystallography; Enzyme mechanism

            • Office: (203) 785-7530
            • Lab: (203) 785-7360

            Herbst, Roy S.

            Research Interests: Early phase clinical trials; Biomarker studies; Personalized medicine for cancer treatment.

            • Office: (203) 785-6879
            • Appt: (203) 200-5864

            Hochster, Howard S

            Research Interests: Clinical research; Pharmacology; Anti cancer drug development; Early clinical trials in cancer

            • Appt: (203) 200-4422

            Hodsdon, Michael Edwin

            Research Interests: Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology

            • Office: (203) 688-2622
            • Lab: (203) 737-2684
            • Appt: (203) 688-2445

            Jordt, Sven-Eric

            Research Interests: Sense of touch and pain in humans and animals; Chemosensory processes in sensory neurons and their role in chemical environmental exposures; Neural sensitization in asthma; Hypersensitivity disorders

            • Office: (203) 823-5181
            • Lab: (203) 737-1560

            Kenney, Patrick A.

            Research Interests: Investigator-initiated and cooperative group trials; Integration of surgery and novel systemic therapies; Renal Cell Carcinoma

            • Appt: (203) 785-2815

            Kluger, Harriet

            Research Interests: Prognostic and predictive markers in melanoma and renal cell carcinoma; Development of new drugs for melanoma and renal cell carcinoma

            • Appt: (203) 200-6622

            Koo, Jaseok Peter

            Research Interests: Cancer prevention and therapy; Lung carcinogenesis; Epithelial cell biology; Personalized medicine; Molecular targets; Drug development; Transcription Factor CREB; Inflammation; Cytokines and chemokines and receptors; Biomarkers for early detection and therapy

              Lacy, Jill

              Research Interests: Clinical research in gastrointestinal malignancies; Gastroesphageal, pancreatic, and colorectal cancers; Brain tumors; Epstein-Barr virus-associated malignancies

              • Appt: (203) 200-4422

              Lindskog, Dieter M.

              Research Interests: Bone graft alternatives; Metastatic disease

              • Office: (203) 785-2579
              • Appt: (203) 737-5656

              Lolis, Elias

              Research Interests: Cancer; Inflammation; Infectious disease; Macromolecular X-ray crystallography; Signaling pathways; Drug design; High throughput screening (HTPS)

              • Office: (203) 785-6233
              • Lab: (203) 737-1526

              Lynch, Thomas James

              Research Interests: Lung cancer; EGFR; Targeted therapy; Personalized medicine

              • Appt: (203) 200-5864

              Michaud, Gaetane Celine

              Research Interests: Complex Airway Disorders; Pleural Disease; Lung Cancer; COPD/Empysema; Decision Support; Lung Cancer Screening

              • Office: (203) 785-4177
              • Appt: (203) 737-5699

              Moliterno, Jennifer

              Research Interests: Clinical trials for brain tumors, personalized medicine for patients with brain tumors

                Mor, Gil G

                Research Interests: Immunology of Gynecologic tumors; Immunology of Implantation; Ovarian Cancer Stem Cells

                • Office: (203) 785-6294
                • Lab: (203) 737-1405

                Parker, Terri Lynn

                • Appt: (203) 200-4363

                Patrizio, Pasquale

                Research Interests: Fertility and Infertility; Cryopreservation; Oocyte biology; Embryonic competence

                • Office: (203) 764-5866
                • Appt: (203) 785-4708

                Peduzzi, Peter Natale

                Research Interests: Clinical trials; Comparative effectiveness research; General statistical methods; Variable selection

                • Office: (203) 785-5615

                Piepmeier, Joseph Massa

                Research Interests: Neuro-oncology; Acoustic neuroma; General neurosurgery; Brain and spinal cord cancer; Brachytherapy; Stereotactic needle biopsy

                • Appt: (203) 785-2791

                Podoltsev, Nikolai Alexandrovich

                • Appt: (203) 200-4363

                Regan, Lynne J

                Research Interests: Mental retardation; Protein-protein interactions; Fragile X Mental Retardation Protein (FMRP); Protein-based nanomaterials

                  Roberts, John D

                  Research Interests: Sickle cell disease; Phase I clinical trials in oncology; Prostate cancer; Bladder cancer; Testicular cancer; Clinical trials design.

                    Rose, Michal Gillian

                    • Office: (203) 937-3421

                    Rutherford, Thomas J.

                    Research Interests: Minimally invasive surgical techniques; Ovarian stem cell research; Micro-RNA; Novel biologic agents for treatment; Early detection of ovarian cancer

                    • Office: (203) 785-6301
                    • Appt: (203) 200-4176

                    Saltzman, W. Mark

                    Research Interests: Bio-compatible polymers, drug delivery systems

                    • Office: (203) 432-4262

                    Sartorelli, Alan Clayton

                    Research Interests: Cancer research; Drug development; Drug resistance

                    • Office: (203) 785-4533
                    • Lab: (203) 785-4534

                    Sasaki, Clarence Takashi

                    Research Interests: Laryngeal physiology; Head and neck cancer

                    • Appt: (203) 785-5430

                    Schepartz, Alanna

                    Research Interests: Organic chemistry; chemical biology; biosynthetic engineering; drug design; synthetic biology; Novel methods to inhibit HIV infection

                    • Office: (203) 432-5094

                    Sessa, William C.

                    Research Interests: Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis

                    • Office: (203) 737-2291

                    Shuch, Brian M.

                    Research Interests: Translational research; Systemic therapy clinical trials; Development of predictive/prognostic biomarkers; Genetic characterization of kidney cancer; Hereditary cancer predisposition

                    • Appt: (203) 785-2815

                    Spiegel, David Adam

                    Research Interests: Design of novel molecules that enhance the recognition of various pathogens, including viruses, by the human immune system

                    • Office: (203) 432-8697

                    Sprenkle, Preston C.

                    Research Interests: Multiparametric MRI; Fusion prostate biopsy; Prostate cancer active surveillance; Nanoparticles; Novel diagnostics for prostate cancer; Focal ablation of cancer; Cryoablation; Irreversible electroporation

                    • Appt: (203) 785-2815

                    Stein, Stacey M

                    • Appt: (203) 200-4422

                    Zhou, Jiangbing

                    Research Interests: Nanomedicine; Brain cancer; Stroke, Traumatic brain injury Neurodegenerative disorders; Drug delivery; Gene therapy; Stem cell therapy;

                    • Office: (203) 785-5327