test

Developmental Therapeutics

Jiangbing Zhou PhD

Assistant Professor of Neurosurgery and of Biomedical Engineering

Research Interests

Nanomedicine; Brain cancer; Stroke, Traumatic brain injury Neurodegenerative disorders; Drug delivery; Gene therapy; Stem cell therapy;


Research Summary

Nanomedicine; Brain cancer stem cells; Neurodegenerative disorders; Drug delivery; Gene therapy; Stem cell therapy; Personalized therapy

Extensive Research Description

Glioblastoma multiforme (GBM) is highly resistant to surgical, pharmacological, and radiation therapies and poses an important public health problem in the US. Recent studies suggest that one of the reasons for failure results from inability to target the most treatment–resistant cell population in the tumor called brain cancer stem cells (BCSCs). Accumulated evidence indicates that BCSCs are the origin of glioma development, as they have the exclusive ability to drive tumor formation and a high capacity to promote angiogenesis. Unfortunately, standard regimens for treating gliomas are not able to effectively eliminate BCSCs. Clearly, improved treatment of malignant gliomas requires effective treatment of BCSCs. However, eradicating BCSCs is a major challenge. Apart from the unavailability of BCSC-specific therapeutic agents, conventional drug delivery approaches do not effectively reach this target population, because the brain possesses the blood brain barrier (BBB). To address these challenges, we develop a multidisciplinary research program that combines recent advances in brain cancer stem cell biology, neural stem cell biology, and emerging nanotechnology. Specifically, we take an integrative systems biology approach to identify novel therapeutic targets for brain cancer. At the same time, we develop multifunctional nanoparticles and engineered stem cells for delivering therapeutic agents or gene therapy to the brain. We expect that the combination of these advances will lead to more effective methods to treat human brain cancer.


Selected Publications

  • Zhou J, Patel TR, Sirianni RW, Strohbehn G, Zheng MQ, Duong N, Schafbauer T, Huttner AJ, Huang Y, Carson RE, Zhang Y, Sullivan DJ Jr, Piepmeier JM, Saltzman WM. Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proc Natl Acad Sci U S A. 2013
  • Zhou J, Liu J, Jiang Z, Patel T, Weller C, Piepmeier JM, Saltzman WM, Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery, Nature Materials, 2011, 11(1):82-90
  • Zhou J, Wulfkuhle J, Zhang H, Gu P, Yang Y, Margolick JB, Liotta LA, Petricoin III E, and Zhang Y. Activation of the PTEN/mTOR/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance. Proc Natl Acad Sci U S A, 2007, 41(104):16158-63

Edit Profile