Developmental Therapeutics

William C. Sessa PhD

Alfred Gilman Professor of Pharmacology and Professor of Medicine (Cardiology); Vice Chairman, Pharmacology; Director, Vascular Biology & Therapeutics Program

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Molecular Medicine, Pharmacology, and Physiology

Office of Student ResearchDevelopmental TherapeuticsVascular Biology and Therapeutics ProgramPharmacology: Sessa LabSkin Diseases Research Center, Yale | Internal Medicine: Diabetes Research CenterNIH T32 ProgramDevelopmental Therapeutics

Research Interests

Vascular endothelium and inflammation; MiRNAs; Vascular development and angiogenesis; Lipid domains and signaling; Atherosclerosis more...


  • Ph.D., New York Medical College, 1989

Selected Publications

  • Harrison, K.D., Miao, R.Q., Fernandez-Hernando, C., Suarez, Y., Davalos, A. and Sessa, W.C. Nogo-B receptor stabilizes Nieman Pick Type C2 protein and regulate intracellular cholesterol trafficking. Cell Metabolism, 10: 208-218 (2009).
  • Schleicher, M., Yu, J., Murata, T., Derakhshan, B., Atochin, D., Qian, L., Kashiwagi, S., Di Lorenzo, A., Harrison, K.D., Huang, P.L and Sessa, W.C. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Science Signaling, 2(82):ra41 (2009).
  • Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M and Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proc Natl Acad Sci U S A. 16;105(37):14082-7 (2008).



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