Mark W Hochstrasser PhD

Eugene Higgins Professor of Molecular Biophysics and Biochemistry and Professor of Molecular, Cellular, and Developmental Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development | Biochemistry, Biophysics and Structural Biology

Office of Student Research

Molecular, Cellular, and Developmental BiologyCancer Center, Yale: Signal TransductionMolecular Biophysics and Biochemistry: Cell Cycle and Transcriptional Regulation; Hochstrasser LabDiabetes Research Center

Research Interests

Adenosinetriphosphatase; Cell Growth Regulation; Chemical Cleavage; Chemical Conjugate; Chimeric Protein; Enzyme Activity; Enzyme Complex; Enzyme Mechanism; Enzyme Structure; Fungal Genetics; Gene Deletion Mutation; Immunoelectron Microscopy; Isozyme; Mass Spectrometry; Mutant; Proteasome; Protein Degradation; Protein Purification; Proteinase; Protooncogene; Saccharomyces Cerevisiae; Transcription Factor; Ubiquitin more...


  • Ph.D., University of Califoria-San Francisco, 1987

Selected Publications

  • Kusmierczyk, A., Kunjappu, M. J., Funakoshi, M. and Hochstrasser, M. A multimeric assembly factor controls formation of alternative 20S proteasomes. Nature Struct. Mol. Biol. 15, 237-244 (2008)
  • Ravid, T. and Hochstrasser, M. (2007). Autoregulation of an E2 enzyme by ubiquitin-chain assembly on its catalytic residue. Nat. Cell Biol. 9:422-427.
  • Deng, M. and Hochstrasser, M. (2006). Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase. Nature 443:827-831.



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