Titus Boggon PhD
Associate Professor of Pharmacology
Research Interests
Structural biology of signal transduction
Research Summary
My laboratory works towards understanding atomic-level mechanisms of signal transduction regulation. We have three primary areas of research.
- Cytokine signal transduction by the Janus kinases;
- Integrin-associated signaling cascades;
- Trp channel regulation.
Our goals are to utilize structural studies to understand the atomic-level mechanisms of signal transduction regulation, to investigate pathologic mechanisms of signal dysregulation, and to aid in drug discovery applications.
Selected Publications
- Li X, Ji W, Zhang R, Folta-Stogniew E, Min W, Boggon TJ. Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting-homology domain of cerebral cavernous malformation 3 (CCM3). Journal of Biological Chemistry. 2011; 286(29):26138-26147
- Li X*, Zhang R*, Zhang H, He Y, Ji W, Min W‡, Boggon TJ‡. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. Journal of Biological Chemistry. 2010; 285(31):24099-24107.
- Petri ET, Celic AS, Kennedy SD, Ehrlich BE, Boggon TJ‡, Hodsdon ME‡. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+ -dependent regulation of polcystin-2 channel activity. PNAS. 2010; 107(20):9176-81
- Chiswell BP, Stiegler AL, Razinia Z, Boggon TJ‡, Calderwood DA‡. PINCH2 and PINCH1 directly compete for binding to the ankyrin repeat domain of the integrin-linked kinase. Journal of Structural Biology. 2010; 70(1):157-163.
- Chiswell BP, Zhang R, Murphy JW, Boggon TJ+, Calderwood DA+. The Structural basis of integrin-linked kinase-PINCH interactions. PNAS. 2008; 105(52):20677-82.
- Celic A*, Petri ET*, Demeler B, Ehrlich BE+, Boggon TJ+. Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. Journal of Biological Chemistry. 2008; 283(42):28305-12.
- Boggon TJ, Li Y, Manley PW, Eck MJ. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue. Blood. 2005 106(3):996-1002.
- Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B. EGFR Mutation and resistance of non–small-cell lung cancer to gefitinib. N Eng J Med. 2005 352(8):786-92.
- Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 304 (5676):1497-500.
- Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L. C-Cadherin ectodomain structure and implications for cell adhesion mechanisms. Science. 2002 296 (5571):1308-1313.
Selected Publications
- Li X, Ji W, Zhang R, Folta-Stogniew E, Min W, Boggon TJ. Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting-homology domain of cerebral cavernous malformation 3 (CCM3). Journal of Biological Chemistry. 2011; 286(29):26138-26147
- Li X*, Zhang R*, Zhang H, He Y, Ji W, Min W‡, Boggon TJ‡. Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity. Journal of Biological Chemistry. 2010; 285(31):24099-24107.
- Petri ET, Celic AS, Kennedy SD, Ehrlich BE, Boggon TJ‡, Hodsdon ME‡. Structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+ -dependent regulation of polcystin-2 channel activity. PNAS. 2010; 107(20):9176-81
- Chiswell BP, Stiegler AL, Razinia Z, Boggon TJ‡, Calderwood DA‡. PINCH2 and PINCH1 directly compete for binding to the ankyrin repeat domain of the integrin-linked kinase. Journal of Structural Biology. 2010; 70(1):157-163.
- Chiswell BP, Zhang R, Murphy JW, Boggon TJ+, Calderwood DA+. The Structural basis of integrin-linked kinase-PINCH interactions. PNAS. 2008; 105(52):20677-82.
- Celic A*, Petri ET*, Demeler B, Ehrlich BE+, Boggon TJ+. Domain mapping of the polycystin-2 C-terminal tail using de novo molecular modeling and biophysical analysis. Journal of Biological Chemistry. 2008; 283(42):28305-12.
- Boggon TJ, Li Y, Manley PW, Eck MJ. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue. Blood. 2005 106(3):996-1002.
- Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B. EGFR Mutation and resistance of non–small-cell lung cancer to gefitinib. N Eng J Med. 2005 352(8):786-92.
- Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 304 (5676):1497-500.
- Boggon TJ, Murray J, Chappuis-Flament S, Wong E, Gumbiner BM, Shapiro L. C-Cadherin ectodomain structure and implications for cell adhesion mechanisms. Science. 2002 296 (5571):1308-1313.
- Santagata S, Boggon TJ, Baird CL, Gomez CA, Zhao J, Shan WS, Myszka DG, Shapiro L. G Protein signaling through tubby proteins. Science. 2001 292 (5524):2041-2050.
- Boggon TJ, Shan WS, Santagata S, Myers SC, Shapiro L. Implication of tubby proteins as transcription factors by structure-based functional analysis. Science. 1999 286 (5447):2119-2125.
Contact Info
- Office
- (203) 785-2943
- Fax
- (203) 737-2027
Lab Website
Research Organizations
Biochemistry, Biophysics and Structural Biology: Cell Cycle and Signal Transduction | Drug Design, Discovery and Mechanism | Membrane Biology and MotionSignal Transduction
Structural Biology
Signal Transduction
