Titus Boggon PhD

Associate Professor of Pharmacology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Biochemistry, Biophysics and Structural Biology

Signal Transduction

Structural Biology


Signal Transduction

Research Interests

Structural biology of signal transduction  more...


  • BS, University of Manchester, UK, 1995
  • Ph.D., University of Manchester, UK, 1998

Selected Publications

  • Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma. Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R. Nature Genetics. 2012; 44(9):1006-1014
  • Structural basis for the small G-protein-effector interaction of Ras-related protein 1 (Rap1) and the adaptor protein Krev interaction trapped 1 (KRIT1). Li X, Zhang R, Draheim KM, Liu W, Calderwood DA, Boggon TJ Journal of Biological Chemistry. 2012; 287(26):22317-22327
  • Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ. Proceedings of the National Academy of Sciences, U.S.A. 2012; 109(40):16107-16112



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