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Recent Publications

Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX.
Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis.
Cancer Cell. 2013 May 21.

Velcheti V, Schalper K, Yao X, Cheng H, Kocoglu M, Dhodapkar K, Deng Y, Gettinger S, Rimm DL.
High SOX2 Levels Predict Better Outcome in Non-Small Cell Lung Carcinomas.
PLoS One. 2013 Apr 19;8(4):e61427.

Kwak M, Mu L, Lu Y, Chen JJ, Brower K, Fan R.
Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction.
Front Oncol. 2013;3:10.

Kwak M, Mu L, Lu Y, Chen JJ, Brower K, Fan R.
Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction.
Front Oncol. 2013;3:10.

Abby L. Cosentino-Boehm, Jacqueline M. Lafky, Tammy M. Greenwood, Kimberly D. Kimbler, Marites C. Buenafe, Yuxia Wang, Adam J. Branscum, Ping Yang, Nita J. Maihle and Andre T. Baron.
Soluble Human Epidermal Growth Factor Receptor 2 (sHER2) as a Potential Risk Assessment, Screening, and Diagnostic Biomarker of Lung Adenocarcinoma

Zhao S, Choi M, Overton JD, Bellone S, Roque DM, Cocco E, Guzzo F, English DP, Varughese J, Gasparrini S, Bortolomai I, Buza N, Hui P, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Carrara L, Pecorelli S, Silasi DA, Ratner E, Azodi M, Schwartz PE, Rutherford TJ, Stiegler AL, Mane S, Boggon TJ, Schlessinger J, Lifton RP, Santin AD.
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma.
Proc Natl Acad Sci U S A. 2013 Jan 28.

Anderson C, Zhou S, Sawin E, Horvitz HR, Hurwitz ME.
SLI-1 Cbl Inhibits the Engulfment of Apoptotic Cells in C. elegans through a Ligase-Independent Function.
PLoS Genet. 2012 Dec;8(12):e1003115.

Davis MJ, Ha BH, Holman EC, Halaban R, Schlessinger J, Boggon TJ.
RAC1P29S is a spontaneously activating cancer-associated GTPase.
Proc Natl Acad Sci U S A. 2013 Jan 2.

Goldberg SB, Schlessinger J, Boyer JL, Herbst RS.
A step towards treating KRAS-mutant NSCLC.
Lancet Oncol. 2012 Nov 27.

Wu Y, Garmire LX, Fan R.
Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment.
Integr Biol (Camb). 2012 Oct 19.

Neumeister VM, Anagnostou V, Siddiqui S, England AM, Zarrella ER, Vassilakopoulou M, Parisi F, Kluger Y, Hicks DG, Rimm DL.
Quantitative Assessment of Effect of Preanalytic Cold Ischemic Time on Protein Expression in BreastCancer Tissues.
J Natl Cancer Inst. 2012 Oct 22.

Ha BH, Davis MJ, Chen C, Lou HJ, Gao J, Zhang R, Krauthammer M, Halaban R, Schlessinger J, Turk BE, Boggon TJ.
Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate.
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16107-12.

Dimou A, Neumeister V, Agarwal S, Anagnostou V, Syrigos K, Rimm DL.
Measurement of Aldehyde Dehydrogenase 1 Expression Defines a Group with Better Prognosis in Patients with Non-Small Cell Lung Cancer.
Am J Pathol. 2012 Aug 6.

Hanna JA, Hahn L, Agarwal S, Rimm DL.
In situ measurement of miR-205 in malignant melanoma tissue supports its role as a tumor suppressor microRNA.
Lab Invest. 2012 Aug 13.

Takezawa K, Pirazzoli V, Arcila ME, Nebhan CA, Song X, de Stanchina E, Ohashi K, Janjigian YY, Spitzler PJ, Melnick MA, Riely GJ, Kris MG, Miller VA, Ladanyi M, Politi K, Pao W.
HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR mutant lung cancers that lack the second-site EGFR T790M mutation.
Cancer Discov. 2012 Sep 5.

Hahn LD, Hoyt C, Rimm DL, Theoharis C.
Spatial spectral imaging as an adjunct to the Bethesda classification of thyroid fine-needle aspiration specimens.
Cancer Cytopathol. 2012 Jul 25. 

Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R.
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.
Nat Genet. 2012 Jul 29.

Gil-Henn H, Patsialou A, Wang Y, Warren MS, Condeelis JS, Koleske AJ.
Arg/Abl2 promotes invasion and attenuates proliferation of breast cancer in vivo.
Oncogene. 2012 Jul 9.

Wysolmerski JJ.
Parathyroid Hormone-Related Protein: An Update.
J Clin Endocrinol Metab. 2012 Jun 28.

Feng C, Neumeister V, Ma W, Xu J, Lu L, Bordeaux J, Maihle NJ, Rimm DL, Huang Y.
Lin28 regulates HER2 and promotes malignancy through multiple mechanisms.
Cell Cycle. 2012 Jul 1;11(13).

Boras-Granic K, Wysolmerski JJ.
PTHrP and breast cancer: more than hypercalcemia and bone metastases.
Breast Cancer Res. 2012 Apr 25;14(2):307.

Macgrath SM, Koleske AJ.
Cortactin in cell migration and cancer at a glance.
J Cell Sci. 2012 Apr 1;125(Pt 7):1621-6.

Hanna JA, Wimberly H, Kumar S, Slack F, Agarwal S, Rimm DL.
Quantitative analysis of microRNAs in tissue microarrays by in situ hybridization.
Biotechniques. 2012 Apr;52(4):235-45.

Wilken JA, Badri T, Cross S, Raji R, Santin AD, Schwartz P, Branscum AJ, Baron AT, Sakhitab AI, Maihle NJ.
EGFR/HER-targeted therapeutics in ovarian cancer.
Future Med Chem. 2012 Mar;4(4):447-69.

Baquero MT, Hanna JA, Neumeister V, Cheng H, Molinaro AM, Harris LN, Rimm DL.
Stathmin expression and its relationship to microtubule-associated protein tau and outcome in breast cancer.
Cancer. 2012 Feb 22.

Politi K, Lynch TJ.
Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer.
Clin Cancer Res. 2012 Feb 8.

Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL.
Molecular classification of nonsmall-cell lung cancer using a 4-protein quantitative assay.
Cancer. 2011 Aug 25. doi: 10.1002/cncr.26450

Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM.
Lung cancer signatures in plasma based on proteome profiling of mouse tumor models.
Cancer Cell. 2011 Sep 13;20(3):289-99.

Chung, C., Mader, C.C., Schmitz, J.C., Atladottir, J., Fitchev, P., Cornwell, M.L., Koleske, A.J., Crawford, S.E., Gorelick, F.
The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancer
(2011) Laboratory Investigation, 91 (5), pp. 732-743.

Pectasides, E., Rampias, T., Kountourakis, P., Sasaki, C., Kowalski, D., Fountzilas, G., Zaramboukas, T., Rimm, D., Burtness, B., Psyrri, A.
Comparative prognostic value of epidermal growth factor quantitative protein expression compared with FISH for head and neck squamous cell carcinoma
(2011) Clinical Cancer Research, 17 (9), pp. 2947-2954.

Sun, T., Aceto, N., Meerbrey, K.L., Kessler, J.D., Zhou, C., Migliaccio, I., Nguyen, D.X., Pavlova, N.N., Botero, M., Huang, J., Bernardi, R.J., Schmitt, E., Hu, G., Li, M.Z., Dephoure, N., Gygi, S.P., Rao, M., Creighton, C.J., Hilsenbeck, S.G., Shaw, C.A., Muzny, D., Gibbs, R.A., Wheeler, D.A., Osborne, C.K., Schiff, R., Bentires-Alj, M., Elledge, S.J., Westbrook, T.F.
Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase
(2011) Cell, 144 (5), pp. 703-718. Cited 4 times.

Mader, C.C., Oser, M., Magalhaes, M.A.O., Bravo-Cordero, J.J., Condeelis, J., Koleske, A.J., Gil-Henn, H.
An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion
(2011) Cancer Research, 71 (5), pp. 1730-1741.

Osborne, C.K., Neven, P., Dirix, L.Y., Mackey, J.R., Robert, J., Underhill, C., Schiff, R., Gutierrez, C., Migliaccio, I., Anagnostou, V.K., Rimm, D.L., Magill, P., Sellers, M.
Gefitinib or placebo in combination with tamoxifen in patients with hormone receptor-positive metastatic breast cancer: A randomized phase II study
(2011) Clinical Cancer Research, 17 (5), pp. 1147-1159.