Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma


Childhood Infratentorial Ependymoma | Childhood Supratentorial Ependymoma | Newly Diagnosed Childhood Ependymoma

What is the purpose of this trial?

This randomized phase III trial is studying maintenance chemotherapy to see how well it
works compared to observation following induction chemotherapy and radiation therapy in
treating young patients with newly diagnosed ependymoma. Drugs used in chemotherapy, such as
vincristine sulfate, carboplatin, cyclophosphamide, etoposide, and cisplatin, work in
different ways to stop the growth of tumor cells, either by killing the cells or by stopping
them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor
cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Specialized radiation
therapy that delivers a high dose of radiation directly to the tumor may kill more tumor
cells and cause less damage to normal tissue. Giving chemotherapy with radiation therapy may
kill more tumor cells and allow doctors to save the part of the body where the cancer

Participation Guidelines

1 Year - 21 Years

Click here for detailed information about who can participate in this trial.

Children's Oncology Group
National Cancer Institute (NCI)
March 2010
Last Updated:
February 23, 2015
Study HIC#:

Clinicaltrials.gov ID: NCT01096368