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A Phase I, Open-label, dose-escalation study of the safety and pharmacokinetics of MPDL3280A administered intravenously as a single agent to patients with locally advanced or metastatic solid tumors or hematologic malignancies

Conditions

Bladder | Breast - Female | Colon | Esophagus | Kidney | Larynx | Lip, Oral Cavity and Pharynx | Lung | Melanoma, skin | Multiple Myeloma | Non-Hodgkin's Lymphoma | Other Male Genital | Pancreas | Prostate | Rectum | Soft Tissue | Stomach | Thyroid

What is the purpose of this trial?

Primary Objectives:

  • To evaluate the safety and tolerability of MPDL3280A administered by intravenous (IV) infusion every 3 weeks (q3w) to patients with locally advanced or metastatic solid tumors
  • To determine the maximum tolerated dose (MTD) and to evaluate the dose-limiting toxicities (DLTs) of MPDL3280A when administered as a single agent to patients by IV infusion q3w
  • To identify a recommended Phase II dose of MPDL3280A

Participation Guidelines

Age:
18 Years and older
Gender:
Both

Click here for detailed information about who can participate in this trial.


Sponsor:
Genentech, Inc.
Dates:
05/03/2012
Last Updated:
Study HIC#:
1203009900