test

A Phase 1 Study of IPI-145 in Patients with Advanced Hematologic Malignancies

Conditions

For Dose Escalation/MTD Confirmation Only: Diagnosis of any advanced hematologic malignancy other than acute leukemia, CML in blast crisis and high risk or intermediate type 2 myelodysplastic syndrome. | For Expansion Cohort 1 Only: Diagnosis of indolent non- Hodgkin lymphoma (iNHL), mantle cell lymphoma (MCL) or chronic lymphocytic leukemia (CLL). | For Expansion Cohort 2 Only: Diagnosis of mature cutaneous or non-cutaneous T cell lymphomas (excluding lymphoblastic lymphoma). | For Expansion Cohort 3 Only: Diagnosis of diffuse large B-cell lymphoma (DLBCL) or transformed follicular NHL. | For Expansion Cohort 4 Only: Diagnosis of myeloproliferative neoplasms (myelofibrosis and all phases of CML), AML, MDS (including intermediate and high risk). | For Expansion Cohort 5 Only: Diagnosis of acute lymphocytic leukemia/lymphoblastic lymphoma (T-cell or B-cell).

Trial Phase

Trial Purpose and Description

Trial Purpose

The purpose of this study is to determine the safety, maximum tolerated dose and pharmacokinetics of IPI-145 in patients with advanced hematologic malignancies.


Participation Guidelines

Age:
18 Years and older
Gender:
Both

Eligibility Criteria

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Sponsor:
Infinity Pharmaceuticals, Inc.
Dates:
November 2012
Last Updated:
Study HIC#:
1208010728