2025
A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability
Lim B, Xu J, Wierzbicki I, Gonzalez C, Chen Z, Gonzalez D, Gao X, Goodman A. A human gut bacterium antagonizes neighboring bacteria by altering their protein-folding ability. Cell Host & Microbe 2025, 33: 200-217.e24. PMID: 39909037, DOI: 10.1016/j.chom.2025.01.008.Peer-Reviewed Original ResearchConceptsHuman gut microbesChaperone complexGut microbesCommunity dynamicsHuman gut bacteriumProtein folding abilityProtein folding capacityHuman gut microbiomeMicrobial community dynamicsGut metagenomesNeighboring bacteriaExpression strainGut bacteriumMammalian gutFitness advantageGut microbiomeAllelic variationGenetic characterizationPathogen-induced inflammationSubstrate aggregationAntagonistic interactionsMicrobesRecipient cellsGutNeighboring cells
2009
Identifying Genetic Determinants Needed to Establish a Human Gut Symbiont in Its Habitat
Goodman AL, McNulty NP, Zhao Y, Leip D, Mitra RD, Lozupone CA, Knight R, Gordon JI. Identifying Genetic Determinants Needed to Establish a Human Gut Symbiont in Its Habitat. Cell Host & Microbe 2009, 6: 279-289. PMID: 19748469, PMCID: PMC2895552, DOI: 10.1016/j.chom.2009.08.003.Peer-Reviewed Original ResearchConceptsHuman gut symbiontHuman gut bacteriumHuman gut commensalAdjacent chromosomal DNAGut symbiontsHuman gut microbiotaGenomic locationMicrobial genesCommunity compositionTransposon mutantsMicrobial adaptationChromosomal DNAHuman symbiontsParallel sequencingGut bacteriumBacteroides thetaiotaomicronRelative abundanceGenetic determinantsGut commensalsSymbiontsVivo selectionMetabolic organCellular compositionGnotobiotic miceGut microbiota
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