2014
Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial
Vilas-Boas A, Fontoura M, Xavier-Souza G, Araújo-Neto C, Andrade S, Brim R, Noblat L, Barral A, Cardoso M, Nascimento-Carvalho C, Matutino A, Barreto B, Silva C, Braga D, Oliveira F, Nogueira G, Oliveira Í, Lorgetto I, Costa I, Araripe J, Vieira J, Neiva L, Santana M, Nobre-Bastos M, Santos P, Câmara S, Carneiro S, Sirmos U, Araújo V, Silva C, Vilas-Boas C, Gantois D, Azevedo F, Maia J, Pirajá L, Jesus P, Fonseca T, Vilar T. Comparison of oral amoxicillin given thrice or twice daily to children between 2 and 59 months old with non-severe pneumonia: a randomized controlled trial. Journal Of Antimicrobial Chemotherapy 2014, 69: 1954-1959. PMID: 24648506, DOI: 10.1093/jac/dku070.Peer-Reviewed Original ResearchConceptsNon-severe pneumoniaTreatment failureOral amoxicillinFirst-line therapyChildhood pneumoniaPrimary outcomeTreat analysisRespiratory complaintsBlinded investigationDaily dosesChest radiographsPatient allocationPneumoniaPatientsIndependent radiologistsAmoxicillinProtocol analysisThriceMonthsChildrenParticipantsFailureConcordant readingsPlaceboTherapy
2012
Differences in evolution of children with non-severe acute lower respiratory tract infection with and without radiographically diagnosed pneumonia
Fontoura M, Matutino A, Silva C, Santana M, Nobre-Bastos M, Oliveira F, Barreto B, Araújo-Neto C, Andrade S, Brim R, Cardoso M, Nascimento-Carvalho C, Pneumopac-Efficacy Study Group. Differences in evolution of children with non-severe acute lower respiratory tract infection with and without radiographically diagnosed pneumonia. Indian Pediatrics 2012, 49: 363-369. PMID: 22080618, DOI: 10.1007/s13312-012-0085-6.Peer-Reviewed Original ResearchConceptsAcute lower respiratory tract infectionChest X-rayLower respiratory tract infectionsRespiratory tract infectionsTract infectionsLower respiratory tract diseaseEvolution of childrenNormal chest X-rayIndependent pediatric radiologistsHigh positive predictive valueUniversity Pediatric HospitalRespiratory tract diseasePositive predictive valueAmoxicillin allergyPulmonary infiltratesPleural effusionClinical symptomsPediatric hospitalAmoxicillin treatmentResultsA totalPulmonary expansionActive surveillancePneumonia casesTract diseaseAntibiotic use
2010
Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin
Fontoura M, Araújo-Neto C, Andrade S, Brim R, Matutino A, Silva C, Santana M, Nobre-Bastos M, Oliveira F, Barreto B, Santos P, Noblat L, Cardoso M, Nascimento-Carvalho C, Group T. Clinical failure among children with nonsevere community-acquired pneumonia treated with amoxicillin. Expert Opinion On Pharmacotherapy 2010, 11: 1451-1458. PMID: 20408745, DOI: 10.1517/14656561003777034.Peer-Reviewed Original ResearchConceptsClinical failureDays of treatmentRisk factorsNonsevere community-acquired pneumoniaAdverse effect frequencyPersistence of feverRadiographic pulmonary infiltratesCommunity-acquired pneumoniaIndependent risk factorClinical failure rateNonsevere pneumoniaPulmonary infiltratesAdverse eventsPleural effusionRespiratory complaintsClinical findingsDifficulty breathingAdverse reactionsSevere diseasePneumonia diagnosisCystic fibrosisMultivariate analysisDemographic dataAmoxicillinOlder children