2023
Assessing emotional characteristics in Asian autistic adults without intellectual disability
Chien Y, Liu C, Chiu Y, Lin C. Assessing emotional characteristics in Asian autistic adults without intellectual disability. Asian Journal Of Psychiatry 2023, 82: 103472. PMID: 36682157, DOI: 10.1016/j.ajp.2023.103472.Peer-Reviewed Original ResearchMeSH KeywordsAdultAutism Spectrum DisorderAutistic DisorderEmotionsFemaleHumansIntellectual DisabilityMaleSchizophreniaConceptsSchutte Emotional Intelligence ScaleAutistic adultsIntellectual disabilityEmotion perceptionSelf-reportEmotional Intelligence ScaleIntelligence ScaleMothers' reportsAutistic malesAutistic featuresEmotional characteristicsSchizophreniaEmotional featuresEmotionsAdultsDisabilitySchuttePerceptionScaleDifficultiesMale
2022
Error patterns of facial emotion recognition in patients with schizophrenia
Lee S, Lin G, Shih C, Chen K, Liu C, Kuo C, Hsieh C. Error patterns of facial emotion recognition in patients with schizophrenia. Journal Of Affective Disorders 2022, 300: 441-448. PMID: 34979185, DOI: 10.1016/j.jad.2021.12.130.Peer-Reviewed Original ResearchConceptsFacial emotion recognitionNegative emotionsError patternsDifferentiation of facesDiscrimination of facesEmotion recognitionHealthy adultsHappy facesResponse biasSchizophreniaTraditional confusion matrixBasic emotionsFacial expressionsEmotionsMethodological issuesAdultsFaceDeficitsFindingsConfusion matrixCliniciansDiscriminationIndividualsInterventionRecognition
2021
A quarter of century after: The changing ecology of psychiatric emergency services
Chen W, Hsieh M, Liao S, Liu C, Liu C, Wu C, Lin Y, Hwang T, Chien Y. A quarter of century after: The changing ecology of psychiatric emergency services. Asia-Pacific Psychiatry 2021, 14: e12487. PMID: 34510765, DOI: 10.1111/appy.12487.Peer-Reviewed Original ResearchConceptsMental disordersPsychiatry consultationSuicide/self-harmStressor-related disordersEmergency psychiatric servicesEmergency psychiatry serviceClinical data of genderCommon mental disordersSchizophrenia spectrumEmergency departmentPsychotic disordersDepressive disorderBipolar disorderPsychiatric servicesPsychiatry servicesPsychiatric emergenciesDisordersClinical trainingPsychiatryNeurosisChief complaintED visitsSchizophreniaMedical CenterData of gender
2020
Development of the CAT-FER: A Computerized Adaptive Test of Facial Emotion Recognition for Adults With Schizophrenia.
Lee S, Lin G, Liu C, Chiu E, Hsieh C. Development of the CAT-FER: A Computerized Adaptive Test of Facial Emotion Recognition for Adults With Schizophrenia. American Journal Of Occupational Therapy 2020, 75: 7501205140p1-7501205140p11. PMID: 33399062, DOI: 10.5014/ajot.2020.043463.Peer-Reviewed Original ResearchConceptsFacial emotion recognitionTest of facial emotion recognitionItem bankComputerized adaptive testingRemoval of misfitting itemsClients’ social functioningDiagnosed mental illnessMeasures of facial emotion recognitionAssessment of facial emotion recognitionAdministration modeEmotion recognitionOccupational therapistsMental illnessDomain scoresMisfitting itemsSocial functioningSevere gender biasSchizophreniaRasch modelAdultsItem difficultyImpact of genderItemsScoresProspective usersDevelopment and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia
Wu C, Luedtke A, Sadikova E, Tsai H, Liao S, Liu C, Gau S, VanderWeele T, Kessler R. Development and Validation of a Machine Learning Individualized Treatment Rule in First-Episode Schizophrenia. JAMA Network Open 2020, 3: e1921660. PMID: 32083693, PMCID: PMC7043195, DOI: 10.1001/jamanetworkopen.2019.21660.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaAntipsychotic medicationPrescribed antipsychotic medicationTreatment success rateTreatment successSchizophrenic disordersFirst-episodeSuccess rateSchizophreniaProbability of treatment successTaiwan National Health Insurance Research DatabaseNational Health Insurance Research DatabaseHealth Insurance Research DatabaseEstimating treatment successValidation sampleIndividualized treatment rulesMedicationPrognostic studyPatientsInvestigated biomarkersClinical implementationDischarge diagnosisClinical observationsDemographic dataPragmatic trialClinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Chien Y, Hwu H, Hwang T, Hsieh M, Liu C, Lin-Shiau S, Liu C. Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 99: 109868. PMID: 31954755, DOI: 10.1016/j.pnpbp.2020.109868.Peer-Reviewed Original ResearchConceptsChronic stable schizophreniaNon-psychiatric controlsDisorganized symptomsChronic stable patientsStable schizophreniaWeeks of antipsychotic treatmentStages of schizophreniaAcute relapseClinical implicationsAntipsychotic treatmentNegative symptomsSchizophreniaStable patientsOxidative stressPlatelet superoxide dismutasePlatelet oxidative stressTreatment responseNitric oxideLipid peroxidationLevels of nitric oxideSymptomsSuperoxide dismutaseTreatment effectsRelapsed patientsRelapse
2019
Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test
Li T, Liu C, Liu C, Hsieh M, Lin Y, Wang E, Hwang T, Chou T. Social cognition in schizophrenia: A network-based approach to a Taiwanese version of the Reading the Mind in the Eyes test. Journal Of The Formosan Medical Association 2019, 119: 439-448. PMID: 31558338, DOI: 10.1016/j.jfma.2019.08.008.Peer-Reviewed Original ResearchConceptsEyes TestNegative emotionsMental statesHealthy controlsSocial cognitive impairmentsChoice patternsStructure of mental statesTaiwanese versionBlunted affectEmotional withdrawalSocial cognitionSocial withdrawalAspect of theoryNegative wordsSchizophreniaEmotionsHigh centralityEmotional aspectsReaction timePoor performanceControl groupImpairmentWithdrawalPatient groupCognitionGenetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia
Liu C, Liu Y, Hwu H, Fann C, Yang U, Hsu P, Chang C, Chen W, Hwang T, Hsieh M, Liu C, Chien Y, Lin Y, Tsuang M. Genetic associations and expression of extra-short isoforms of disrupted-in-schizophrenia 1 in a neurocognitive subgroup of schizophrenia. Journal Of Human Genetics 2019, 64: 653-663. PMID: 30976040, DOI: 10.1038/s10038-019-0597-1.Peer-Reviewed Original ResearchConceptsDisrupted-in-schizophrenia 1Deficient sustained attentionSchizophrenia patientsContinuous Performance TestFrequency of AA genotypeRisk polymorphismsNeurocognitive subgroupsAssociated with schizophreniaEBV-transformed lymphocytesSustained attentionAA genotypeG alleleMRNA expression levelsA allelePatientsFamilial loadingIntron 4Genetic variantsSchizophreniaIsoform transcriptsGenetic associationSNPsExpression levelsIsoformsESV1
2018
Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases
Liu C, Lin Y, Liu C, Hsieh M, Chien Y, Hwang T, Hwu H. Trajectories after first‐episode psychosis: Complement to ambiguous outcomes of long‐term antipsychotic treatment by exploring a few hidden cases. Early Intervention In Psychiatry 2018, 13: 895-901. PMID: 29927087, DOI: 10.1111/eip.12696.Peer-Reviewed Original ResearchConceptsFirst-episode psychosisLong-term antipsychotic treatmentAntipsychotic treatmentRecurrence of psychotic symptomsCourse of chronic schizophreniaLow-dose antipsychoticsChronic schizophreniaDysthymic statesPsychotic symptomsDiagnostic stabilityWord lettersRemission criteriaPsychosisAmbiguous informationProbability of relapseCoping strategiesImpending relapseAmbiguous outcomesDiscontinued medicationAntipsychoticsPersonalized formulationsMedication adherencePsychosocial factorsEarly interventionGroup of patientsShared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia
Huang J, Liu C, Hwang T, Chen Y, Hsu Y, Hwu H, Lin Y, Hsieh M, Liu C, Chien Y, Tseng W. Shared and distinct alterations of white matter tracts in remitted and nonremitted patients with schizophrenia. Human Brain Mapping 2018, 39: 2007-2019. PMID: 29377322, PMCID: PMC6866389, DOI: 10.1002/hbm.23982.Peer-Reviewed Original ResearchConceptsGeneralized fractional anisotropyGeneralized fractional anisotropy valuesAdequate antipsychotic treatmentNegative symptom scoresNonremission groupWhite matter tract integrityWhite matter integrityHealthy controlsRemission stateWhite matter tract bundlesWhite matter tractsReduced integrationAntipsychotic treatmentNonremitted patientsSchizophrenia patientsSymptomatic remissionIllness durationAnalysis of covarianceSchizophreniaDiffusion spectrum imagingTract integrityPost hoc analysisFractional anisotropyMedication dosesEducation years
2017
Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia
Chen C, Cheng M, Liu C, Liu C, Lin K, Hwu H. Seroprevalence survey of selective anti-neuronal autoantibodies in patients with first-episode schizophrenia and chronic schizophrenia. Schizophrenia Research 2017, 190: 28-31. PMID: 28341002, DOI: 10.1016/j.schres.2017.03.012.Peer-Reviewed Original ResearchConceptsAnti-neuronal autoantibodiesLeucine-rich glioma-inactivated-1N-methyl-D-aspartateContactin-associated protein-like 2First-episode schizophreniaAnti-NMDA receptor autoantibodiesA-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acidAssociated with psychiatric disordersGlioma-inactivated-1Blood samplesNeuronal cell surface proteinsArchived blood samplesNeuronal surface proteinsCerebral spinal fluidProtein-like 2Chronic schizophreniaReceptor autoantibodiesClinical presentationAutoimmune encephalopathyTreatment resistancePsychiatric disordersCorrect diagnosisSchizophreniaAutoantibodiesSpinal fluid
2016
Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits
Liu Y, Wang S, Hwu H, Fann C, Yang U, Yang W, Hsu P, Chang C, Wen C, Tsai-Wu J, Hwang T, Hsieh M, Liu C, Chien Y, Fang C, Faraone S, Tsuang M, Chen W, Liu C. Haplotypes of the D-Amino Acid Oxidase Gene Are Significantly Associated with Schizophrenia and Its Neurocognitive Deficits. PLOS ONE 2016, 11: e0150435. PMID: 26986737, PMCID: PMC4795637, DOI: 10.1371/journal.pone.0150435.Peer-Reviewed Original ResearchConceptsSingle-nucleotide polymorphismsAssociated with schizophreniaIntron 8Genomic regionsIntron 1Genetic variantsLarger patient samplesD-amino-acid oxidase geneNovel single‐nucleotide polymorphismsHaplotype association analysisSingle-locus analysisExecutive functionD-amino acid oxidaseFunctional genetic variantsSustained attentionNeurocognitive functionSchizophreniaEpstein-Barr virus-transformed lymphocytesMRNA expressionHaplotype blocksSingle-locusHaplotype distributionVirus-transformed lymphocytesHaplotype frequenciesAssociation analysisTherapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries
Garay R, Citrome L, Samalin L, Liu C, Thomsen M, Correll C, Hameg A, Llorca P. Therapeutic improvements expected in the near future for schizophrenia and schizoaffective disorder: an appraisal of phase III clinical trials of schizophrenia-targeted therapies as found in US and EU clinical trial registries. Expert Opinion On Pharmacotherapy 2016, 17: 921-936. PMID: 26831200, DOI: 10.1517/14656566.2016.1149164.Peer-Reviewed Original ResearchConceptsCognitive impairment associated with schizophreniaSchizoaffective disorderNegative symptomsDopamine D2 receptor partial agonistTreatment of cognitive impairment associated with schizophreniaD2 receptor partial agonistTreating positive symptomsReceptor partial agonistEU clinical trial registriesAdd-on compoundsTardive dyskinesiaPositive symptomsGoal of recoverySchizophreniaPartial agonistAntipsychoticsSchizoaffectivePhase III of clinical developmentTherapeutic improvementDisordersClinical Trials RegistrySymptomsPharmacodynamic profileClinical developmentAcademic medical centerAberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue
Lai C, Lee S, Scarr E, Yu Y, Lin Y, Liu C, Hwang T, Hsieh M, Liu C, Chien Y, Udawela M, Gibbons A, Everall I, Hwu H, Dean B, Chen W. Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue. Translational Psychiatry 2016, 6: e717-e717. PMID: 26784971, PMCID: PMC5068884, DOI: 10.1038/tp.2015.213.Peer-Reviewed Original ResearchConceptsPeripheral miRNAsState-dependent markersDiagnostic of schizophreniaHsa-miR-34aPostmortem brain tissueAberrant expression of microRNAsCaudate putamenSchizophreniaSubcortical regionsAcute stateExpression of microRNAsSeven-miRNARemission stateBrain samplesAberrant expressionClinically useful biomarkersExpression levelsBrainMonths of hospitalizationPartial remission stateAge-dependent increaseMiRNA dysregulationMiRNAsPartial remissionClinical symptoms
2015
Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis
Wu C, Hwang T, Chen Y, Hsu Y, Lo Y, Liu C, Hwu H, Liu C, Hsieh M, Chien Y, Chen C, Tseng W. Primary and secondary alterations of white matter connectivity in schizophrenia: A study on first-episode and chronic patients using whole-brain tractography-based analysis. Schizophrenia Research 2015, 169: 54-61. PMID: 26443482, DOI: 10.1016/j.schres.2015.09.023.Peer-Reviewed Original ResearchConceptsDorsolateral prefrontal cortexBilateral DLPFCFirst-episode patientsWhite matter connectivityFirst-episodeChronic patientsBilateral dorsolateral prefrontal cortexFirst-episode schizophreniaWidespread white matter abnormalitiesBilateral temporal polesDebilitating mental disorderReduced white matter connectivityRight arcuate fasciculusSuperior longitudinal fasciculus IDuration of illnessAssociated with clinical variablesCallosal fibersBetween-group analysisWhite matter tractsWhite matter abnormalitiesPrefrontal cortexImpaired connectivityTemporal poleArcuate fasciculusCerebral white matter
2013
Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia
Tseng H, Chen S, Liu C, Howes O, Huang Y, Hsieh M, Liu C, Shan J, Lin Y, Hwu H. Facial and Prosodic Emotion Recognition Deficits Associate with Specific Clusters of Psychotic Symptoms in Schizophrenia. PLOS ONE 2013, 8: e66571. PMID: 23818944, PMCID: PMC3688591, DOI: 10.1371/journal.pone.0066571.Peer-Reviewed Original ResearchConceptsEmotion recognition abilityCluster of psychotic symptomsPsychotic symptomsEmotion recognition taskHappy emotionHealthy participantsDysfunction of brain systemsSeverity of psychotic symptomsDeficits of emotion recognitionPresentation of psychotic symptomsDSM-IV diagnostic criteriaRecognition taskPANSS total scoreSensory modalitiesEmotion recognitionRecognition abilityEvaluation of symptomatologySeverity of clinical symptomsHappy prosodyNegative symptomsPerseveration errorsWAIS-IIIDSM-IVEmotional processingBrain systems
2012
Zotepine-related myopathy in a patient with schizophrenia
Chen I, Hsieh M, Hwang T, Liu C. Zotepine-related myopathy in a patient with schizophrenia. European Journal Of Clinical Pharmacology 2012, 69: 725-726. PMID: 22797903, DOI: 10.1007/s00228-012-1346-y.Peer-Reviewed Original ResearchPsychopathology, rehospitalization and quality of life among patients with schizophrenia under home care case management in Taiwan
Chang L, Lin Y, Chang H, Chen Y, Huang W, Liu C, Liu C, Hwu H. Psychopathology, rehospitalization and quality of life among patients with schizophrenia under home care case management in Taiwan. Journal Of The Formosan Medical Association 2012, 112: 208-215. PMID: 23537867, DOI: 10.1016/j.jfma.2012.01.018.Peer-Reviewed Original ResearchConceptsNegative symptom subscale scoreSymptom subscale scoresAssociated with higher positive symptomsPositive and Negative Syndrome ScaleSubscale scoresGeneral psychopathology scoreNegative Syndrome ScaleSocio-occupational dysfunctionAssessment of FunctioningDuration of rehospitalizationPANSS scoresPositive symptomsSyndrome ScalePatients' psychopathologyPsychopathology scoresPsychopathologySchizophreniaLength of inpatient stayQuality of lifeCase managementNon-ICMDecrease rehospitalizationCase management programGAFRehospitalization rates
2011
Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management
Chang L, Lin Y, Kuo T, Chang H, Liu C, Liu C, Hwu H, Yang C. Autonomic Modulation and Health-Related Quality of Life among Schizophrenic Patients Treated with Non-Intensive Case Management. PLOS ONE 2011, 6: e26378. PMID: 22073161, PMCID: PMC3208549, DOI: 10.1371/journal.pone.0026378.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome Scale for SchizophreniaSchizophrenic patientsNegative symptomsAssociated with more negative symptomsNon-ICMHealth-related quality of lifeSchizophreniaAutonomic modulationHealth-related qualityAnticholinergic useQuality of lifeAssociated with autonomic dysfunctionHigher VAS scoreCommunity settingsIncreased cardiovascular mortalityEQ-5DBody mass indexClinical variablesVisual analogue scaleEQ-VASSymptomsImpairmentHeart rate variability measuresCardiovagal dysfunctionScores
2010
Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states
Huang G, Tsai H, Hwu H, Chen C, Liu C, Hua M, Chen W. Patient subgroups of schizophrenia based on the Positive and Negative Syndrome Scale: composition and transition between acute and subsided disease states. Comprehensive Psychiatry 2010, 52: 469-478. PMID: 21193177, DOI: 10.1016/j.comppsych.2010.10.012.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScaleNegative Syndrome ScaleNegative symptomsSyndrome ScaleWhole syndromeFlorid symptomsNeurobiological studies of schizophreniaPartial syndromesSubgroup of schizophreniaStudies of schizophreniaReality distortionAcute schizophreniaNeurocognitive variablesLatent class analysisNeurobiological studiesSchizophreniaSymptom patternsPatient subgroupsAcute stateClass analysisSociodemographic variablesPAN dataSymptomsHostilityRegression extension