2022
Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy
Korenblik R, Olij B, Aldrighetti LA, Hilal MA, Ahle M, Arslan B, van Baardewijk LJ, Baclija I, Bent C, Bertrand CL, Björnsson B, de Boer MT, de Boer SW, Bokkers RPH, Rinkes IHMB, Breitenstein S, Bruijnen RCG, Bruners P, Büchler MW, Camacho JC, Cappelli A, Carling U, Chan BKY, Chang DH, choi J, Font JC, Crawford M, Croagh D, Cugat E, Davis R, De Boo DW, De Cobelli F, De Wispelaere JF, van Delden OM, Delle M, Detry O, Díaz-Nieto R, Dili A, Erdmann JI, Fisher O, Fondevila C, Fretland Å, Borobia FG, Gelabert A, Gérard L, Giuliante F, Gobardhan PD, Gómez F, Grünberger T, Grünhagen DJ, Guitart J, Hagendoorn J, Heil J, Heise D, Herrero E, Hess GF, Hoffmann MH, Iezzi R, Imani F, Nguyen J, Jovine E, Kalff JC, Kazemier G, Kingham TP, Kleeff J, Kollmar O, Leclercq WKG, Ben SL, Lucidi V, MacDonald A, Madoff DC, Manekeller S, Martel G, Mehrabi A, Mehrzad H, Meijerink MR, Menon K, Metrakos P, Meyer C, Moelker A, Modi S, Montanari N, Navines J, Neumann UP, Peddu P, Primrose JN, Qu X, Raptis D, Ratti F, Ridouani F, Rogan C, Ronellenfitsch U, Ryan S, Sallemi C, Moragues JS, Sandström P, Sarriá L, Schnitzbauer A, Serenari M, Serrablo A, Smits MLJ, Sparrelid E, Spüntrup E, Stavrou GA, Sutcliffe RP, Tancredi I, Tasse JC, Udupa V, Valenti D, Fundora Y, Vogl TJ, Wang X, White SA, Wohlgemuth WA, Yu D, Zijlstra IAJ, Binkert CA, Bemelmans MHA, van der Leij C, Schadde E, van Dam RM. Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy. CardioVascular And Interventional Radiology 2022, 45: 1391-1398. PMID: 35790566, PMCID: PMC9458562, DOI: 10.1007/s00270-022-03176-1.Peer-Reviewed Original ResearchConceptsFuture liver remnant hypertrophyHepatic vein embolizationMulticenter prospective single-arm trialResectable colorectal cancer liver metastasesColorectal cancer liver metastasesProspective single-arm trialFeasibility of resectionCancer liver metastasesDisease-free survivalSingle-arm trialSmall FLRPrimary endpointSecondary endpointsFLR hypertrophyLiver metastasesOverall survivalProspective trialVein embolizationLiver functionSafety profileArm trialLiver volumeWeek 1Week 3Study centers
2011
Indications and Contraindications for Portal Vein Embolization
Madoff D, Vauthey J. Indications and Contraindications for Portal Vein Embolization. 2011, 123-128. DOI: 10.1007/978-1-84882-122-4_13.Peer-Reviewed Original ResearchPortal vein embolizationTotal liver volumeVein embolizationUse of PVEFuture liver remnant volumeLiver remnant volumePatient body sizeFLR volumePerioperative outcomesPatient ageSurgical candidatesLiver diseaseRemnant volumeSurgical interventionLiver volumeCT volumetryHealthy liverParticular patientPatientsContraindicationsEmbolizationAgeMultiple factorsCirrhosisComorbidities
2005
Portal Vein Embolization in Preparation for Major Hepatic Resection: Evolution of a New Standard of Care
Madoff DC, Abdalla EK, Vauthey JN. Portal Vein Embolization in Preparation for Major Hepatic Resection: Evolution of a New Standard of Care. Journal Of Vascular And Interventional Radiology 2005, 16: 779-790. PMID: 15947041, DOI: 10.1097/01.rvi.0000159543.28222.73.Peer-Reviewed Original ResearchConceptsPortal vein embolizationMajor hepatic resectionHepatic resectionVein embolizationFunctional hepatic reserveChronic liver diseasePortal blood flowNondiseased portionHospital stayHepatic reservePreoperative managementLiver diseaseLiver volumeBlood flowEmbolic agentResectionLiver regenerationMultidisciplinary approachEmbolizationPatientsLiverImaging techniquesComplex casesContraindicationsComplicationsTranshepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV: Improving Hypertrophy and Resection Outcomes with Spherical Particles and Coils
Madoff DC, Abdalla EK, Gupta S, Wu TT, Morris JS, Denys A, Wallace MJ, Morello FA, Ahrar K, Murthy R, Lunagomez S, Hicks ME, Vauthey JN. Transhepatic Ipsilateral Right Portal Vein Embolization Extended to Segment IV: Improving Hypertrophy and Resection Outcomes with Spherical Particles and Coils. Journal Of Vascular And Interventional Radiology 2005, 16: 215-225. PMID: 15713922, DOI: 10.1097/01.rvi.0000147067.79223.85.Peer-Reviewed Original ResearchMeSH KeywordsAcrylic ResinsAdultAgedBile Duct NeoplasmsCarcinoma, HepatocellularCause of DeathEmbolization, TherapeuticFemaleFollow-Up StudiesGelatinHepatectomyHumansHypertrophyLength of StayLiverLiver NeoplasmsMaleMicrospheresMiddle AgedPolyvinyl AlcoholPortal VeinRetrospective StudiesSafetyTomography, Spiral ComputedTreatment OutcomeConceptsTotal estimated liver volumeRight portal vein embolizationTris-acryl microspheresRight PVEPortal vein embolizationRight hepatectomyFLR volumeResection rateVein embolizationLiver volumeEstimated liver volumeMalignant hepatobiliary diseaseProgressive liver insufficiencyMedian hospital stayPercent of patientsExtended right hepatectomyResult of sepsisFuture liver remnantPostembolization syndromeTomographic volumetryHospital stayFLR hypertrophyPostoperative outcomesResection outcomesBiliary cancer
2003
Portal Vein Embolization with Polyvinyl Alcohol Particles and Coils in Preparation for Major Liver Resection for Hepatobiliary Malignancy: Safety and Effectiveness—Study in 26 Patients1
Madoff DC, Hicks ME, Abdalla EK, Morris JS, Vauthey JN. Portal Vein Embolization with Polyvinyl Alcohol Particles and Coils in Preparation for Major Liver Resection for Hepatobiliary Malignancy: Safety and Effectiveness—Study in 26 Patients1. Radiology 2003, 227: 251-60. PMID: 12616006, DOI: 10.1148/radiol.2271012010.Peer-Reviewed Original ResearchConceptsPreoperative portal vein embolizationFuture liver remnantMedian hospital stayPortal vein embolizationPolyvinyl alcohol particlesHepatobiliary malignanciesLobar hypertrophyHospital stayFLR hypertrophyHepatic resectionVein embolizationLiver volumeAlcohol particlesPreoperative PVERatio of FLRAdvanced hepatobiliary malignanciesEstimated liver volumePostprocedure complication rateMajor liver resectionUnderlying liver diseasePercutaneous transhepatic approachTotal liver volumePVA particlesPostembolization syndromeComplication rate