2024
Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis
Schmitzer L, Kaczmarz S, Göttler J, Hoffmann G, Kallmayer M, Eckstein H, Hedderich D, Kufer J, Zimmer C, Preibisch C, Hyder F, Sollmann N. Macro- and microvascular contributions to cerebral structural alterations in patients with asymptomatic carotid artery stenosis. Cerebrovascular And Brain Metabolism Reviews 2024, 44: 1629-1642. PMID: 38506325, PMCID: PMC11418673, DOI: 10.1177/0271678x241238935.Peer-Reviewed Original ResearchInternal carotid artery stenosisInternal carotid artery stenosis patientsCerebral blood flowCarotid artery stenosisPeak width of skeletonized mean diffusivitySmall vessel diseaseContralateral alterationsArtery stenosisAsymptomatic internal carotid artery stenosisWhite matterAsymptomatic carotid artery stenosisCapillary transit time heterogeneityCerebral structural alterationsCortical thicknessMagnetic resonance imagingHemodynamic alterationsRisk factorsPatientsDTI metricsResonance imagingDorsal cingulate cortexBlood flowIschemic strokeMean diffusivityStenosis
2020
Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI
Kaczmarz S, Göttler J, Petr J, Hansen M, Mouridsen K, Zimmer C, Hyder F, Preibisch C. Hemodynamic impairments within individual watershed areas in asymptomatic carotid artery stenosis by multimodal MRI. Cerebrovascular And Brain Metabolism Reviews 2020, 41: 380-396. PMID: 32237952, PMCID: PMC7812517, DOI: 10.1177/0271678x20912364.Peer-Reviewed Original ResearchConceptsInternal carotid artery stenosisRelative oxygen extraction fractionRelative cerebral blood volumeCerebral blood flowCapillary transit time heterogeneityOxygen extraction capacityCarotid artery stenosisHemodynamic impairmentCerebrovascular reactivityArtery stenosisUnilateral internal carotid artery stenosisAsymptomatic internal carotid artery stenosisAsymptomatic carotid artery stenosisAge-matched healthy controlsMultimodal MRICerebral blood volumeOxygen extraction fractionTransit time heterogeneityMicrovascular impairmentStroke riskOxygenation parametersWidespread dysfunctionHealthy controlsHemodynamic parametersIndividual patients