2024
In vivo neuropil density from anatomical MRI and machine learning
Akif A, Staib L, Herman P, Rothman D, Yu Y, Hyder F. In vivo neuropil density from anatomical MRI and machine learning. Cerebral Cortex 2024, 34: bhae200. PMID: 38771239, PMCID: PMC11107380, DOI: 10.1093/cercor/bhae200.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingSynaptic densityNeuropil densityCellular densityArtificial neural networkNeural networkPositron emission tomographyAnatomical magnetic resonance imagingHealthy subjectsSynaptic activityMRI scansMachine learning algorithmsBrain's energy budgetEmission tomographyIn vivo MRI scansResonance imagingTissue cellularityLearning algorithmsDiffusion magnetic resonance imagingMachine learningMicroscopic interpretationInterpretation of functional neuroimaging dataIndividual predictionsSubjects
2014
Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior
Shulman RG, Hyder F, Rothman DL. Insights from Neuroenergetics into the Interpretation of Functional Neuroimaging: An Alternative Empirical Model for Studying the Brain's Support of Behavior. Cerebrovascular And Brain Metabolism Reviews 2014, 34: 1721-1735. PMID: 25160670, PMCID: PMC4269754, DOI: 10.1038/jcbfm.2014.145.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehaviorBrainFunctional NeuroimagingHumansMagnetic Resonance SpectroscopyMental ProcessesModels, NeurologicalPositron-Emission TomographyRadiographyConceptsFunctional magnetic resonance imagingMagnetic resonance imagingNeuronal activityMental moduleObservable behaviorBrain activityDistinct psychological mechanismsResonance imagingBaseline neuronal activityPositron emission tomography (PET) imagingEmission Tomography ImagingPsychological mechanismsMental processesFunctional neuroimagingBrain supportAwake humansAlternative empirical modelsNeurophysiological parametersBaseline activityTomography imagingTheoretical assumptionsSensory systemsIncremental signalNeuroimagingElectrical recordings
2013
Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy
Hyder F, Fulbright RK, Shulman RG, Rothman DL. Glutamatergic Function in the Resting Awake Human Brain is Supported by Uniformly High Oxidative Energy. Cerebrovascular And Brain Metabolism Reviews 2013, 33: 339-347. PMID: 23299240, PMCID: PMC3587823, DOI: 10.1038/jcbfm.2012.207.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCognitionElectroencephalographyEnergy MetabolismFemaleGlutamineHumansMagnetic Resonance ImagingMalePositron-Emission TomographyRodentiaVisual CortexWakefulnessConceptsFunctional magnetic resonance imagingMagnetic resonance spectroscopy studyAwake resting stateFuture clinical investigationsMagnetic resonance imagingHigh resting activityAwake human brainGray matter regionsGlutamatergic functionGlutamatergic signalingMetabolic measuresClinical investigationAwake stateResting activityVisual cortexGlucose utilizationResonance imaging