Weight Status of Children With Sickle Cell Disease
Chawla A, Sprinz PG, Welch J, Heeney M, Usmani N, Pashankar F, Kavanagh P. Weight Status of Children With Sickle Cell Disease. Pediatrics 2013, 131: e1168-e1173. PMID: 23460681, DOI: 10.1542/peds.2012-2225.Peer-Reviewed Original ResearchConceptsSickle cell diseaseBaseline Hb levelsHb levelsBMI percentileWeight statusCell diseaseHigher baseline Hb levelsSCD-related complicationsRetrospective chart reviewObesity-related conditionsOverweight/obesityRecent clinic visitYears of ageCalendar year 2007Select comorbiditiesChart reviewClinic visitsDL increaseElevated BMIHemoglobin levelsObese statusSickle genotypeUnderweight individualsHb SSDemographic informationCandidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea
Green NS, Ender KL, Pashankar F, Driscoll C, Giardina PJ, Mullen CA, Clark LN, Manwani D, Crotty J, Kisselev S, Neville KA, Hoppe C, Barral S. Candidate Sequence Variants and Fetal Hemoglobin in Children with Sickle Cell Disease Treated with Hydroxyurea. PLOS ONE 2013, 8: e55709. PMID: 23409025, PMCID: PMC3567082, DOI: 10.1371/journal.pone.0055709.Peer-Reviewed Original ResearchConceptsSickle cell diseaseFetal hemoglobin levelsHemoglobin levelsCell diseaseFetal hemoglobinBaseline levelsAdult sickle cell diseasePediatric sickle cell diseaseSubset of childrenPharmacologic therapyHydroxyurea therapyClinical severityPediatric diseasesInduced levelsSignificant associationTherapeutic inductionCandidate single nucleotide polymorphismsDiseaseSingle nucleotide polymorphismsHemoglobinSequence variantsChildrenTherapyBaselineHydroxyurea