Featured Publications
Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation
Yu KE, Kwon H, Dussik CM, Cahill SV, Back J, Alder KD, Lee FY. Enhancement of Impaired MRSA‐Infected Fracture Healing by Combinatorial Antibiotics and Modulation of Sustained Inflammation. Journal Of Bone And Mineral Research 2020, 37: 1352-1365. PMID: 35616626, DOI: 10.1002/jbmr.4570.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusExcessive inflammationAntibiotic treatmentFracture healingTrametinib therapyInfected fracturesPro-inflammatory cytokine levelsPostoperative antibiotic administrationSetting of infectionMale C57BL/6 miceSystemic antibiotic treatmentAdjunctive therapeutic agentMRSA-infected miceImpaired callus formationFemoral fracture modelTherapeutic cohortCytokine levelsMRSA infectionMusculoskeletal infectionsPostoperative intervalsSystemic vancomycinAntibiotic administrationCytokine analysisC57BL/6 miceIntramedullary nailing
2020
Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies
Yu K, Song L, Kang HP, Kwon HK, Back J, Lee FY. Recalcitrant methicillin-resistant Staphylococcus aureus infection of bone cells: Intracellular penetration and control strategies. Bone And Joint Research 2020, 9: 49-59. PMID: 32435455, PMCID: PMC7229311, DOI: 10.1302/2046-3758.92.bjr-2019-0131.r1.Peer-Reviewed Original ResearchMethicillin-resistant Staphylococcus aureus (MRSA) infectionsEarly antibiotic administrationHours of injuryStandard of careStaphylococcus aureus infectionBone resident cellsEffect of cefazolinBone Joint ResAntibiotic regimensAntibiotic administrationCombined administrationAntibiotic treatmentAureus infectionProtective effectSurgical preparationMRSA growthOpen fracturesPreparation agentsDetergent susceptibilityPrimary murine osteoblastsBacterial bioburdenMRSAColony formationRifampicinBone cells