2020
Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus
Alder K, White A, Chung Y, Lee I, Back J, Kwon H, Cahill S, Hao Z, Li L, Chen F, Lee S, Riedel M, Lee F. Systemic Parathyroid Hormone Enhances Fracture Healing in Multiple Murine Models of Type 2 Diabetes Mellitus. JBMR Plus 2020, 4: e10359. PMID: 32382692, PMCID: PMC7202418, DOI: 10.1002/jbm4.10359.Peer-Reviewed Original ResearchRisk of fractureFracture healingMurine modelType 2 diabetes mellitusPTH expressionEffects of hPTHIntermittent systemic administrationSuitable murine modelPrevalence of T2DMAge-related osteoporosisDiabetes mellitusPresent studySystemic administrationSkeletal fragilityMultisystemic diseaseT2DMOsteoporotic phenotypeBone qualityBone fracturesCalcium homeostasisMesenchymal stem cellsBone phenotypeHormone productionHPTHHealing
2019
Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus.
Henderson S, Ibe I, Cahill S, Chung YH, Lee FY. Bone Quality and Fracture-Healing in Type-1 and Type-2 Diabetes Mellitus. Journal Of Bone And Joint Surgery 2019, 101: 1399-1410. PMID: 31393433, DOI: 10.2106/jbjs.18.01297.Peer-Reviewed Original ResearchConceptsType 2 diabetesPerioperative complicationsDiabetic patientsGlycemic controlBone healthType 1Type 2 diabetes mellitusNormal bone mineral densityPerioperative glycemic controlNon-diabetic patientsEarly bone lossSurgical site infectionAppropriate glycemic controlUnion of fractureRisk of fractureBone mineral densityType 1 diabetesAntiresorptive therapyOperative interventionDiabetes mellitusSclerostin antibodySite infectionMedical managementParathyroid hormonePostoperative management