Featured Publications
Biocompatibility of platinum-based bulk metallic glass in orthopedic applications
Loye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications. Biomedical Materials 2021, 16: 045018. PMID: 33873168, DOI: 10.1088/1748-605x/abf981.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiocompatible MaterialsGlassHumansMaleMesenchymal Stem CellsMiceMice, Inbred C57BLNanotubesOsteoblastsOsteoclastsPlatinumSurface PropertiesX-Ray MicrotomographyConceptsBulk metallic glassPt-BMGPlatinum-based bulk metallic glassMetallic glassesConventional metallic implantsCorrosion resistanceHigh strengthMechanical testingOrthopedic applicationsBone applicationsMetallic implantsMicro-computed tomographyAmorphous metalsTitaniumWearBiocompatibilitySimilar biocompatibilityFurther processingGlassDuctilityNanopatternsNanoscaleApplicationsMesenchymal stem cellsStrength
2011
Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study
Son J, Kim JM, Han M, Choi S, Lee F, Oh D. Bone Regeneration of Tibial Segmental Defect Using Isotropic-Pore Structures Hydroxyapatite/Alumina Bi-Layered Scaffold: In Vivo Pilot Study. Journal Of Long-Term Effects Of Medical Implants 2011, 21: 159-167. PMID: 22043974, DOI: 10.1615/jlongtermeffmedimplants.v21.i2.60.Peer-Reviewed Original ResearchMeSH KeywordsAluminum OxideAnimalsBiocompatible MaterialsBone RegenerationDogsDurapatiteMicroscopy, Electron, ScanningModels, AnimalPilot ProjectsTibiaTissue ScaffoldsConceptsBi-layer scaffoldLayered scaffoldsBi-layered scaffoldIsotropic pore structureLarge segmental defectsEnergy dispersive spectroscopyBone regenerationAlumina scaffoldsCoating techniqueDispersive spectroscopyPore sizeSegmental defectsTibia modelBone substituteTibial segmental defectInner layerAluminaElectron microscopyOuter layerBone defectsMicro-CTNew bone formationLayerScaffoldsPorosity
2008
What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles?
Tuan RS, Lee FY, T Konttinen Y, Wilkinson JM, Smith RL. What are the local and systemic biologic reactions and mediators to wear debris, and what host factors determine or modulate the biologic response to wear particles? Journal Of The American Academy Of Orthopaedic Surgeons 2008, 16 Suppl 1: s42-8. PMID: 18612013, PMCID: PMC2714366, DOI: 10.5435/00124635-200800001-00010.Peer-Reviewed Original ResearchMeSH KeywordsBasic Helix-Loop-Helix Transcription FactorsBiocompatible MaterialsBone ResorptionDinoprostoneEndothelial CellsFibroblastsForeign-Body ReactionHumansInterleukin-1Interleukin-6Interleukin-8Joint ProsthesisMacrophage Colony-Stimulating FactorOsteoclastsOsteogenesisProsthesis FailureRANK LigandStem CellsT-LymphocytesTumor Necrosis Factor-alphaConceptsBone lossTNF-alphaIL-1Inflammatory bone lossPro-osteoclastogenic cytokinesGene functionHost inflammatory responsePeriprosthetic bone lossBone marrow-derived mesenchymal stem cellsMarrow-derived mesenchymal stem cellsGenetic variationBasic science dataMolecular mechanismsMesenchymal stem cellsMechanism of actionPeriprosthetic inflammationIL-6IL-8M-SCFInflammatory responseT cellsStem cellsAltered susceptibilityBiologic effectsOsteoprogenitor cells
1998
Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement
Benevenia J, Lee F, Buechel F, Parsons J. Pathologic supracondylar fracture due to osteolytic pseudotumor of knee following cementless total knee replacement. Journal Of Biomedical Materials Research 1998, 43: 473-477. PMID: 9855207, DOI: 10.1002/(sici)1097-4636(199824)43:4<473::aid-jbm16>3.0.co;2-9.Peer-Reviewed Original ResearchConceptsWear debrisForeign body reactionPathologic fractureSupracondylar fracturesReplacement arthroplastyDebris of polyethyleneTotal knee replacement arthroplastyCementless total knee replacementAggressive granulomatous lesionsBody reactionKnee replacement arthroplastyJoint replacement arthroplastySoft tissue massTotal knee replacementAseptic prosthetic looseningTotal knee prosthesisMassive osteolysisGranulomatous lesionsTumorlike lesionsKnee replacementProsthetic looseningTissue massFemoral componentLesionsKnee prosthesis