2010
The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis
Reilly RF, Peixoto AJ, Desir GV. The Evidence-Based Use of Thiazide Diuretics in Hypertension and Nephrolithiasis. Clinical Journal Of The American Society Of Nephrology 2010, 5: 1893-1903. PMID: 20798254, DOI: 10.2215/cjn.04670510.Peer-Reviewed Original ResearchMeSH KeywordsAntihypertensive AgentsBlood PressureDrug Therapy, CombinationEvidence-Based MedicineHumansHypertensionNephrolithiasisSecondary PreventionSodium Chloride Symporter InhibitorsTreatment OutcomeConceptsUse of indapamideUrinary calcium excretionThiazide-type diureticsRandomized clinical trialsTreatment of hypertensionEvidence-based useDose-response effectPaucity of dataInitial therapyCalcium excretionHypertensive patientsOlder patientsThiazide diureticsStone recurrencePatient groupClinical trialsDrug classesSafe optionHypertensionDiureticsAvailable evidenceNephrolithiasisHydrochlorothiazideChlorthalidoneSafe track record
1993
Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex
Ellison DH, Biemesderfer D, Morrisey J, Lauring J, Desir GV. Immunocytochemical characterization of the high-affinity thiazide diuretic receptor in rabbit renal cortex. American Journal Of Physiology 1993, 264: f141-f148. PMID: 8430824, DOI: 10.1152/ajprenal.1993.264.1.f141.Peer-Reviewed Original ResearchConceptsThiazide diuretic receptorRenal distal tubulesDistal tubulesUrinary NaCl excretionRenal cortical membranesThick ascending limbRabbit kidney cortexApical membraneThiazide diureticsRenal cortexRabbit renal cortexCortical membranesProximal tubulesAscending limbSubpopulation of cellsNaCl excretionThiazide receptorKidney cortexIntense stainingWestern blotMonoclonal antibodiesRabbit kidneyImmunocytochemical characterizationPrincipal cellsReceptors
1991
Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex
Ellison D, Morrisey J, Desir G. Solubilization and partial purification of the thiazide diuretic receptor from rabbit renal cortex. Biochimica Et Biophysica Acta 1991, 1069: 241-249. PMID: 1932064, DOI: 10.1016/0005-2736(91)90131-q.Peer-Reviewed Original ResearchConceptsHigh-affinity receptorRenal cortexCortical homogenatesDistal tubulesHigh-performance liquid chromatographyDistal tubule fragmentsRenal cortical microsomesRenal distal tubulesThiazide diuretic receptorRenal cortical membranesExclusion high performance liquid chromatographyRat renal cortexRenal cortical homogenatesCortical microsomesRabbit renal cortexReceptor densityCortical membranesSize-exclusion high-performance liquid chromatographyRabbit receptorThiazide receptorCl- transport pathwaysPercoll gradient centrifugationDiuretic drugsTubule fragmentsReceptors